DiscoverInsideEDM SMS Banner 03
Issue 6|July 2016  l Previous Issues

Message from the Head of School


Image of Professor Paul Donaldson
Professor Paul Donaldson

Dear Colleagues,

It is hard to believe that the first semester teaching is finished, exams are over and we are preparing for the start of the second semester. On top of doing our “day jobs” it is great to see the school’s successes in the latest grant rounds. This success is an endorsement of the excellence of our research and the hard work of our researchers, especially in a very competitive research environment.

I also wish to congratulate Ray Gilbert, Mary Spellman and Vicky Tsang who as members of the HazTRAC Subject Matter Experts team were recently awarded the inaugural Vice Chancellor’s Excellence Award for Health, Safety and Wellbeing.

The goal of the HazTRAC project was to identify and implement across the whole University a single inventory management system for all chemical and biological (including hazardous and restricted) materials, and lab consumables. The result of the project is the impending rollout of SciQuest ERM - an inventory management and procurement tool that will securely track and manage the full life cycle of material from point of purchase, transport, storage, and use through to the disposal of hazardous and restricted materials.

The HazTRAC project represents an infrastructural investment by the University to meet its strategic objective of making the institution ‘A safe and healthy environment’. To make sure we all contribute to this objective, the University is trying to foster an organisational culture that is characterised by attitudes to health and safety which are proactive, responsible and based on mutual respect and regard.

Hence our next school forum will provide an opportunity for all staff and graduate students to hear updates and progress on University initiatives to continually create a safe place to work and study. Lee Dewhurst, Associate Director for Health, Safety and Wellbeing will be attending and will provide insight into how the University plans to work with you to provide quality advice, support and resources to manage the risk associated with everything we do.

I encourage you to attend the forum, which will be followed by a social mixer to mark the end of semester and to celebrate our successes. I look forward to seeing as many of you as possible on the Wednesday, 13 July.

Regards,

Professor Paul Donaldson
Head of School, School of Medical Sciences
Faculty of Medical and Health Sciences

 

Staff News


Image of Anna Lawerence
Anna Lawerence

Congratulations to Anna Laurenson who has been appointed to the new position of Bequest Coordinator for the Human Body Bequest Programme within the Department of Anatomy and Medical Imaging. This role incorporates responsibilities previously facilitated by academics within the department.

Over the last two years Anna has been responsible for some aspects of the role alongside her work as a Support Technician for the Medical Sciences Learning Centre and the Clinical Skills Centre, where she started in 2006. Her working background is as a registered nurse at Auckland City Hospital and in general practice, as a reference librarian for Auckland City Libraries and as a landscape gardener. She continues to assist her husband in the running of their general practice in Mount Eden and is a mum to their three children aged 15 years to 22 years.

Anna looks forward to continue working in and developing the new Bequest Coordinator role. She feels extremely privileged to be working alongside such great colleagues within the Human Body Bequest Programme, Human Anatomy Laboratory and Medical Sciences Learning Centre.

 

Recent Awards and Accolades

Image of Distinguished Professor Richard Faull

Congratulations to our internationally renowned brain researcher Distinguished Professor Richard Faull who was recently awarded for his outstanding contributions to health research excellence.

The awards were presented by Health Research Council Chief Executive, Professor Kath McPherson and Board Chair Dr Lester Levy at the University of Auckland’s annual “Celebrating Research Excellence Awards”

 

Image of Dr Ali Mirjalili published book 'Anatomy for GSSE'
Dr Ali Mirjalili published book 'Anatomy for GSSE'

Congratulations to Dr Ali Mirjalili who has just released an app and published a book called “Anatomy for GSSE.

Dr Ali Mirjalili and Mr Robbie McPhee (Graphic Artist, University of Otago) recently launched an app on the App store entitled "Anatomy for GSSE”. The app is a collection of questions and short notes to assist junior doctors and surgical trainees to successfully sit their GSSE (Generic Surgical Sciences Examination) exams. A hard copy (ISBN: 978-7-89456-719-2) will be published in June by the People's Medical Publishing House (PMPH), the largest Chinese Medical publishing company under the Chinese Ministry of Health.

The questions in the app are designed to highlight key surgical anatomy areas, and are supplemented with images which replicate generic surgical sciences examination (GSSE) spot-test type questions. The short notes are intended as a quick reference guide which junior doctors and surgeons can refer to whilst "between patients" or while preparing for surgery. Illustrations accompanying the short notes highlight particular anatomical relationships which can sometimes be difficult to grasp or understand.

Mr McPhee has previously had his illustrations published in the 150th anniversary edition of Gray's Anatomy, and on covers of several international journals.

To purchase the app please click here

 

Image of Dr Kimberly Mellor and Professor Janusz Lipski
From Left: Dr Kimberly Mellor and Professor Janusz Lipski

Well done to Dr Kimberley Mellor on being awarded the University of Auckland Early Career Researcher award. The funding from this award will support pilot experiments investigating the tissue-specific regulation of glycogen in diabetes using a novel proteomics approach. It will also provide funds for travel costs for Kimberley to attend international conferences in China and Australia, where she has been invited to present her research.

Congratulations to Professor Janusz Lipski, on being awarded the Butland teaching award for Excellence in Research Supervision.

Image of From left: Lee Dewhurst, Ray Gilbert, Tim Layt, Peter Mayne, Keith Richards, Mary Spellman, Vicky Tsang and Chancellor Ian Parton
From left: Lee Dewhurst, Ray Gilbert, Tim Layt, Peter Mayne, Keith Richards, Mary Spellman, Vicky Tsang and Chancellor Ian Parton

SMS HazTRAC Subject Matter Experts win Vice Chancellor’s Excellence Award

Ray Gilbert, Mary Spellman and Vicky Tsang from the School of Medical Sciences, were one half of the team that were recently awarded the inaugural Vice Chancellor’s Excellence Award for Health, Safety and Wellbeing.

The six HazTRAC Subject Matter Experts (SMEs); Ray, Mary, Vicky and three other staff from Faculty of Science were selected ”for their work on the implementation and standardisation of SciQuest ERM University-wide, substantially reducing the risk from both chemicals and biologicals to staff and students.” The implementation of SciQuest and associated practices is expected to have a significant University wide impact with an associated longevity going forward.

The SMEs have put in many hundreds of hours of work to help set up the implementation and have all been involved as members of the reference group. Ray and Prof Paul Donaldson are also members of the Steering Committee.

The SMEs have communicated across all levels of the project and across faculties and service divisions. This should ensure the resulting SciQuest implementation would cover all the University and regulatory requirements for chemical and biological risk. It will also ensure the systems for purchasing and tracking these items is of maximum benefit to staff and students.

The award is part of the revamped VC’s Excellence Awards – Health, Safety and Wellbeing was recognised as a category for the first time this year. The award was open to all staff and students of the University. The award was presented to the SME team at the Alumni Marquee on 5 May.

Postgraduate successes


Image of Professor Paul Donaldson, Ankita Umapathy and Dr Julie Lim
From Left: Professor Paul Donaldson, Ankita Umapathy and Dr Julie Lim

Congratulations to the following students who have successfully defended their theses:

Michelle Munro - successfully defended her doctoral thesis ‘Multi-Scale Cardiomyocyte Organisation as a Determinant of Cardiac Function’

Supervised by Professor Christian Soeller and co-supervised by Dr David Crossman and Dr Marie Ward

Ankita Umapathy - received The Vice-Chancellor’s Prize for Best Doctoral Thesis. Ankita’s thesis was entitled ‘Glutathione metabolism and transport pathways in the anterior rat eye: Is the lens a reservoir of glutathione?’

Supervised by Dr Julie Lim and Professor Paul Donaldson

Teaching news


Appointment of Course Directors for the Postgraduate courses in Biomedical Science

Dr Rohit Ramachandra (Physiology) is the newly appointed MEDS I 734 Course Director. Rohit has experience with MEDSCI 725, which is going to be the template for this new course but with a wider range of experimental design questions and data sets. Rohit will be convening a curriculum workshop to develop the content of this course and I will invite you to participate in the development of this course

MEDCSI 744 Co-course directors – Dr Julie Lim (Physiology/Optometry) and Dr Scott Graham (Pharmacology). Both Julie and Scott are Sir Charles Hercus Research Fellows, who have established their own independent laboratories within the School. In addition, they have links with groups in SBS which is important for biomedical students based in SBS will be required to take this course. All staff will have opportunities to contribute to this course as supervisors of student projects.

Biomedical Science Honours – Dr Justin Dean (Physiology). Justin is the current coordinator of the Biomedical Science orientation programme, is a member of the current Biomedical Board of Studies and is, therefore, a logical candidate to step up to this new role.

Research developments


     

Congratulations to the staff who have been awarded grants

  • HRC Grants
    Professor Michael Dragunow, Pharmacology
    Vascular and inflammatory mediators of neurodegeneration
    $4,999,998 (60 months)

    Dr Kimberley Mellor, Physiology
    ‘Fructose and the heart: targeting novel mechanisms of diabetic cardiomyopathy.’
    $1,172,435

    Dr Rohit Ramchandra, Physiology
    ‘Physiological pacing to improve cardiac output in heart failure.’
    $1,115,696

    Associate Professor Michael Hay, ACSRC
    ‘Novel radiosensitisers for head and neck cancer.’
    $1,198,115

    Professor Peter Shepherd, Molecular Medicine and Pathology
    ‘Potentiation of targeted cancer therapies by statins.’
    $1,174,005

  • Auckland Heart Group Charitable Trust/Doctoral Scholarship
    Prof Alistair Young, Anatomy and Medical Imaging awarded $115,000

  • Auckland Medical Research Foundation/AMRF Kelliher Charitable Trust
    Dr Petr Tomek, ACSRC awarded $ 30,000
  • Diabetes New Zealand – Auckland Branch/Graeme Mack Research Fund
    Dr Troy Merry, School of Medical Sciences awarded $ 113,500

  • Institut national de la santé et de la recherche médicale/Collaborative Research Programme
    Associate Professor Michelle Glass, Pharmacology awarded $ 85,162

  • Lottery Health/Lottery Health Research Projects
    Dr David Crossman, Physiology awarded $54,228
    Dr Alan Davidson, Molecular Medicine and Pathology awarded $ 30,800
    Professor Michael Findlay, Oncology awarded $ 82,882
    Dr Dean Singleton, ACSRC awarded $45,000

  • Lottery Health/Lottery Health Shared Equipment
    Professor William Denny, ACSRC awarded $59,470

  • Maurice and Phyllis Paykel Trust/MPPT Project Grant
    Professor Stefan Bohlander, Molecular Medicine and Pathology awarded $20,000
    Dr Francis Hunter, ACSRC awarded $10,000
    Dr Fiona Radcliff, Molecular Medicine and Pathology awarded $12,000
    Dr Siouxsie Wiles, Molecular Medicine and Pathology awarded $15,000

  • School of Medicine Foundation/PJ Smith Freemasons Fellowship
    Dr Sai Fung, ACSRC awarded $9,380

  • School of Medicine Foundation/School of Medicine Foundation Project
    Professor Michael Findlay, Oncology awarded $ 159,284
  • The New Zealand Breast Cancer Foundation/The New Zealand Breast Cancer Foundation
    Associate Professor Nuala Helsby, Molecular Medicine and Pathology awarded $37,269
    Dr Dean Singleton, ACSRC awarded $80,000

 

High Impact Papers 

Kwakowsky, A., Potapov, K., Kim, S., Peppercorn, K., Tate, W. P., and Ábrahám IM has recently published a ‘Treatment of beta amyloid 1-42 (Aβ1-42)-induced basal forebrain cholinergic damage by a non-classical estrogen signalling activator in vivo’ (2016).Scientific reports 6

In Alzheimer’s disease, there is a loss in cholinergic innervation targets of basal forebrain which implicating substantial cognitive decline. Amyloid beta peptide (Aβ1–42) accumulates in AD that is highly toxic for basal forebrain cholinergic neurons.

We reported here that after Aβ1–42 injection into mouse basal forebrain,a single dose of 4-estren-3α, 17β-diol (estren), the non-classical estradiol pathway activator, restored loss of cholinergic cortical projections and also attenuated the Aβ1–42-induced learning deficits. These findings indicated that selective activation of non-classical intracellular estrogen signalling has a potential to treat the damage of cholinergic neurons in Alzheimer’s disease.

Read the paper

Athena Ferreira, Mark J. Bolland, and Mark G. Thomas published a paper entitled ‘Meta-analysis of randomised trials comparing a penicillin or cephalosporin with a macrolide or lincosamide in the treatment of cellulitis or erysipelas.’

Cellulitis is a common, potentially severe, infection of the skin and the underlying tissues. The most commonly recommended treatments are penicillin antimicrobials, such as flucloxacillin or benzyl penicillin. Macrolide and lincosamide antibiotics, such as erythromycin or clindamycin, are commonly regarded as second-line agents.

The meta-analysis they conducted compared the outcomes in patients with cellulitis treated, either with a penicillin or cephalosporin or with a macrolide or lincosamide. They found that treatment with a macrolide or lincosamide had a similar efficacy and risk of adverse effects as treatment with a beta-lactam. This may lead to increased use of an oral macrolide or lincosamide in the treatment of patients with cellulitis.

Read the paper

Lab of the month


Image of Cardiac Structure and Function Group
Cardiac Structure and Function Group

The Cardiac Structure and Function Group comprises of physiologists, clinicians and bioengineers from the School of Medical Sciences, Auckland City Hospital, and the Auckland Bioengineering Institute. They have an international reputation for high-quality experimental, imaging, and modelling work on the structure and function of normal and abnormal hearts. This has led to a strong citation record and collaborations with research groups in Australia, Europe, Asia and North America.

The primary focus of their current research, funded by an HRC Programme grant, is investigating how myocardial fibrosis leads to abnormal electrical activity in the heart and often fatal cardiac arrhythmia. Fibrosis is an increase in collagen which occurs naturally with age, but also has a number of other causes including heart attack and heart failure. 

In this work they undertake in vivo and ex vivo electrical mapping to record the spread of waves of electrical activation across the atria or ventricles. Recording of electrical signals is achieved using various techniques, many of which have been developed by their group over 20 years, including arrays of transmural needle electrodes, epicardial electrode socks, intracardiac balloon catheters, and body surface electrode strips, as well as optical techniques that utilise voltage-sensitive dyes to measure transmembrane potential.

Image of Optical mapping of rat heart
Optical mapping of rat heart

They then use the extended-volume confocal imaging systems developed by their group, MRI, and micro-CT to capture three-dimensional images of myocardial geometry and microstructure.  This allows them to examine regional details of myocardial structure from the cellular level to the whole heartand relate these to specific characteristics of the electrical activity in those regions. 

The rich datasets gathered during their experiments are large and complex, and interpretation of such data requires sophisticated computer modelling and analysis techniques, many of which are developed within their group.

This combination of experiment, imaging and modelling within the one research group is a particular advantage and provides great potential for developing valuable insights into the relationship between myocardial fibrosis and cardiac arrhythmia.  They expect their research to lead to more specifically targeted therapies and improved clinical outcomes for cardiac patients. 

Administration matters


Change to Promotions Applications

Applications for Professor close on 15 July with all other applications being due on 15 August. Information on the process and links to all the forms and policies is available at Academic promotions.  

Key changes in University course and teaching evaluation

From Semester One, summative (formal University) evaluations are to be conducted entirely online through the SET tool, which will be integrated with Canvas. All evaluations will take place in the 'evaluation period' (week 10-12), with the exception of those delayed until the last teaching week to include all members of a teaching team.  
The University will use revised standardised questionnaires for courses. The questionnaires are available at: www.auckland.ac.nz/evaluate.


Reports will be provided by SET as per the provisions of the Policy, by role. Academic Heads will have access to individual course and teaching reports, and will receive a summary report. The University wil provide Deans with a faculty summary report. In time, additional reporting will be available for academic managers within SMR.

For more information regarding course and teaching evaluations see the Enhancement and Evaluation of Courses and Teaching website.

Improvements to University international travel

As at Monday 2 May 2016, the University has moved to Allianz Global Assistance, our travel insurer, to provide international medical and security travel assistance services. Should an emergency or unforeseen event happen while overseas, University travellers will need only one contact for instant advice and support. If you travel on University business, please take a moment to familiarise yourself with the international medical and security travel assistance support available.