School of Medical Sciences

Placental drug transport & metabolism

Principal investigator

Research interests

Drug exposure during pregnancy is increasingly common in modern society, with risks to the developing embryo/fetus. The placenta is the gatekeeper to the fetus through which drugs and other chemical must pass. Placental drug transporters are able to reduce fetal exposure to a wide variety of xenobiotics through their ability to efflux substrates from fetoplacental tissues into the maternal circulation for excretion. We are studying the action and regulation of a number of drug efflux pumps in the placenta, and are also exploring their role as transporters of endogenous lipid substrates, protectors of placental viability and facilitators of placental cell differentiation and function.