School of Medical Sciences


Bone growth

Principal investigators


Staff


  • Mrs Karen Callon

Research


In the last few years, our bone cell and molecular biology research group has investigated the correlative relationship between fat mass and bone mass that we observed in clinical studies. A number of peptide hormones have been recently identified that positively influence fat and bone mass and we are studying these hormone effects on bone metabolism using in vitro and in vivo models.

Selected references


Menaa C., Barsony J., Reddy S.V., Cornish J., Cundy T., Roodman G.D. (2000). 1,25-Dihydroxyvitamin D3 hypersensitivity of osteoclast precursors from patients with Paget's disease. Journal of Bone & Mineral Research 15:228-36.

Cornish J., Callon K.E., King A.R., Cooper G.J., Reid I.E. (1998). Systemic administration of amylin increases bone mass, linear growth, and adiposity in adult male mice. American Journal, of Physiology 275 (4 Pt 1):E694-9.