School of Medical Sciences

Antioxidants/Oxidative stress in vivo

Principal investigators


Although many compounds can scavenge free radicals in vitro, such events do not necessarily extrapolate to animals or humans. A range of tissue culture and animal studies are being utilised to consider whether specific diets or dietary components are able to protect against oxidative damage in vivo. Protection may occur directly or through modulation of xenobiotic metabolism.

Selected references

Helsby N., Khu S., Pearson A., Tingle M, Ferguson L. (2000). Studies on the mechanism of cancer protection by wheat bran: ability to modulate xenobiotic metabolosing enzymes. Mutation Research in press.

McPherson R., Tingle M, Ferguson, L.R. (2001). Effect of chronic dietary exposure to 2-Amino-3-Methyl-Imidazo[4,5-f] Quinoline on xenobiotic metabolising enzymes in the male Fischer 344 rat - The characterisation of a model for chemoprevention studies. Eur.J.Nutr. (submitted).