School of Medical Sciences

Signal transduction in diseases lab - about us

Principal investigator

I moved back to New Zealand from London in Sept 2004 and my research here will continue to be in the broad area of signal transduction related to type-2 diabetes.

Type-2 diabetes is reaching epidemic proportions in the world and New Zealand is no exception. The causes and consequences of Type-2 diabetes are tightly linked with defects in the way insulin works, a condition termed "insulin resistance". The insulin resistant and diabetic states are associated with a deranged metabolic state in which glucose and lipid levels are elevated and altogether these factors are key to the development of the severe complications associated with diabetes. These complications include blindness, kidney failure and circulatory problems that result in limb amputations and heart disease.