School of Medical Sciences


Three dimensional PK/PD modelling using information from 3D tissue cultures

Spatially resolved PK/PD modelling


mcl_flux_apparatus
microregion

Cell kill is shown by poltting the surviving fraction versus oxygen concentration at each point in the tumour microregion

Measure drug diffusion
> Mathematical model >

Predict cancer kill

Advantages


  • Cost- and time-effective
  • Reduced animal numbers used for testing drugs