Brain development and repair group

Principal Investigator

Research team

Research Interests

Our aim is to characterise the molecular and cellular mechanisms underlying the impairments in white matter and cortical maturation that occur following preterm birth. Our current focus includes:

  • Astrogliosis as an inhibitory environment for cell plasticity.
  • Oligodendrocyte cell biology and responses to injury.
  • The physiological and pathophysiological roles of the extracellular matrix glycosaminoglycan hyaluronic acid in oligodendrocyte progenitor cell (OPC) proliferation and maturation.
  • Impact of prenatal insults on cortical development and neuronal maturation.
  • Glial/axonal signaling.

The use of high-field strength MRI for imaging of brain injury The overall goal is to develop therapeutic strategies targeted to overcome oligodendrocyte injury and myelination deficits, and impaired cortical maturation, that occur following infection or cerebral hypoxia-ischemia in the developing brain.