Publications
Tercel, M., Atwell, G.J., Yang, S., Stevenson, R.J., Botting, K.J., Boyd, M., Smith, E., Anderson, R.F., Denny, W.A., Wilson, W.R., Pruijn, F.B. Hypoxia-activated prodrugs: substituent effects on the properties of nitro secoo-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents. Journal of Medicinal Chemistry, 2009, 52(22), 7258-7272. Read more
Milbank, J.B., Stevenson, R.J., Ware, D.C., Chang, J.Y., Tercel, M., Ahn, G.O., Wilson, W.R., Denny, W.A. Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1HH-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins. Journal of Medicinal Chemistry, 2009, 52(21), 6822-6834. Read more
Wilson, W.R., Stribbling, S.M., Pruijn, F.B., Syddall, S.P., Patterson, A.V., Liyanage, H.D.S., Smith, E., Botting, K.J., Tercel, M. Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine NN3 DNA minor groove alkylators. Molecular Cancer Therapeutics, 2009, 8(10), 2903-2913. Read more
Ahn, G., Botting, K.J., Patterson, A.V., Ware, D.C., Tercel, M. and Wilson W.R. Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator. Biochemical Pharmacology, 2006, 71, 1683-1694. Read more
Tercel, M., Stribbling, S.M., Sheppard, H., Siim, B. G., Wu, K., Pullen, S.M., Botting, J., Wilson, W.R., Denny, W.A. Unsymmetrical DNA Cross-Linking Agents: Combination of the CBI and PBD Pharmacophores. Journal of Medicinal Chemistry, 2003, 46, 2132-2151. Read more
Tercel, M., Gieseg, M.A., Milbank, J.B., Boyd, M., Fan, J-Y., Tan, K.L., Wilson, W.R., Denny, W.A. Cytotoxicity and DNA Interaction of the Enantiomers of 6-Amino-3-(chloromethyl)-1-[(5,6,7-trimethoxyindol-2-yl)carbonyl]indoline (Amino-secoo-CI-TMI). Chemical Research in Toxicology, 1999, 12, 700-706. Read more
Milbank, J.B., Tercel, M., Atwell, G.J., Wilson, W.R., Hogg, A., Denny, W.A. Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-secoo-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity. Journal of Medicinal Chemistry, 1999, 42(4), 649-658. Read more
Tercel, M., Gieseg, M.A., Denny, W.A., Wilson, W.R. Synthesis and cytotoxicity of amino-secoo DSA: an amino analogue of the DNA alkylating agent duocarmycin SA. Journal of Organic Chemistry, 1999, 64, 5946-5953. Read more
Atwell, G.J., Tercel, M., Boyd, M., Wilson, W.R., Denny, W.A. Synthesis and cytotoxicity of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2-dihydro-3HH-benz[e]indole (amino-seco-CBI-TMI) and related 5-alkylamino analogues: new DNA minor groove alkylating agents. Journal of Organic Chemistry, 1998, 63, 9414-9420. Read more