Auckland Cancer Society Research Centre


Bioanalysis systems

In the development of anti-cancer drugs, it is increasingly important to measure their concentrations accurately in blood and tissues. The ACSRC has extensive facilities for extracting drugs from blood and tissues, and analysing the concentrations of the drug and its breakdown products (which are usually metabolites produced in the body).

We offer world class training in the use of high performance liquid chromatography and mass spectrometry, and our bioanalysis cluster provides support for pharmacokinetic studies in the development of our drugs as well as servicing other departments in the University.

Mass spectrometry

We use mass spectrometry to measure drug concentrations with very high sensitivity and identify drug metabolites in blood and tissues.

  • Agilent Triple Quadrupole Mass Spectrometer (QQQ)
  • Agilent LC/MS Mass Spectrometer (LC/MS)

High performance liquid chromatography

We make extensive use of HPLC for high throughput quantitation of drug concentrations in our in vitro and in vivo pharmacokinetic studies.

  • Agilent HPLC systems

 

User charges

Costs for using the facilities are outlined in the table below. Non-commercial rates are intended for public good grant funded research, whereas commercial rates refer to commercially funded research (including HOD accounts). All new users are required to undergo a one hour training session with our Senior Technician; the charge for which is equivalent to the hourly rate of the machine being used. A grant number MUST be supplied for all bookings that are made. Cancellations of less than one day's notice will be charged for the time booked (unless a replacement user is organised by the person who has made the booking).

Equipment Non-commercial (Rate/hour) Commercial (Rate/hour)
QQQ $60.00 $90.00
LC/MS $40.00 $60.00
HPLC $18.00 $27.00

Contact persons


Related publications

  • Bashiri G, Antoney J, Jirgis E.N.M., Shah M.V., Ney B, Copp J, Stutely S.M., Sreebhavan S, Palmer B, Middleditch M, Tokuriki N, Greening C, Baker E.N., Scott C, Jackson C.J. (2018) A revised biosynthetic pathway for the cofactor F420 in bacteria. BioRxiv
  • Tang J.S., Vissers M.C.M., Anderson R.F., Srebhavan S, Bozonet S.M., Melton L.D. (2018) Bioavailable blueberry-derived phenolic acids at physiological concentration enhance Nrf2- regulated antioxidant responses in human vascular endothelial cells.  Journal of Molecular Nutrition and food research 62(5)
  • Chang H, Telang R.S., Sreebhavan S, Tingle M, Thorne P.R., Vlajkovic S.M. (2017) Pharmacokinetic properties of adenosine amine congener in cochlear perilymph after systemic administration. BioMed Res Int. 2017 Article ID 8091462