School of Medical Sciences


Human Neurodegenerative Diseases Group - publications

  • Waldvogel HJ, Baer K, Gai WP, Gilbert RT, Rees MI, Mohler H, Faull RLM (2008) Differential localization of GABA(A) receptor subunits within the substantia nigra of the human brain: An immunohistochemical study. Journal of Comparative Neurology 506:912-929.
  • Aponso PM, Faull RLM, Connor B (2007) Increased progenitor cell proliferation and astrogenesis in the partial progressive 6-hydroxydopamine model of Parkinson's disease. Neuroscience (Epub ahead of print).
  • Gibbons HM, Hughes SM, Van Roon-Mom W, Greenwood JM, Narayan PJ, Teoh HH, Bergin PM, Mee EW, Wood PC, Faull RLM, Dragunow M (2007) Cellular composition of human glial cultures from adult biopsy brain tissue. Journal of Neuroscience Methods 166:89-98.
  • Dragunow M, Cameron R, Narayan P, O'Carroll S (2007) Image-based high-throughput quantification of cellular fat accumulation. Journal of Biomolecular Screening 12:999-1005.
  • Curtis MA, Faull RLM, Eriksson PS (2007) The effect of neurodegenerative diseases on the subventricular zone. Nature Reviews Neuroscience 8:712-723.
  • Narayan PJ, Gibbons HM, Mee EW, Faull RLM, Dragunow M (2007) High throughput quantification of cells with complex morphology in mixed cultures. Journal of Neuroscience Methods 164:339-349.
  • Lim JH, Gibbons HM, O'Carroll SJ, Narayan PJ, Faull RLM, Dragunow M (2007) Extracellular signal-regulated kinase involvement in human astrocyte migration. Brain Research 1164:1-13.
  • Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi MA, Sathasivam K, Cha JH, Hannan AJ, Hayden MR, Leavitt BR, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RLM, Olson JM, Bates GP, Jones L, Luthi-Carter R (2007) Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Human Molecular Genetics 16:1845-1861.
  • Wilkie RP, Vissers MC, Dragunow M, Hampton MB (2007) A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils. Infection & Immunity 75:3256-3263.
  • Waldvogel HJ, Baer K, Allen KL, Rees MI, Faull RLM (2007) Glycine receptors in the striatum, globus pallidus, and substantia nigra of the human brain: an immunohistochemical study. Journal of Comparative Neurology 502:1012-1029.
  • Liu YW, Mee EW, Bergin P, Teoh HH, Connor B, Dragunow M, Faull RLM (2007) Adult neurogenesis in mesial temporal lobe epilepsy: a review of recent animal and human studies. Current Pharmaceutical Biotechnology 8:187-194.
  • Curtis MA, Eriksson PS, Faull RLM (2007) Progenitor cells and adult neurogenesis in neurodegenerative diseases and injuries of the Basal Ganglia. Clinical and Experimental Pharmacology & Physiology 34:528-532.
  • Baer K, Eriksson PS, Faull RLM, Rees MI, Curtis MA (2007) Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone. Experimental Neurology 204:828-831.
  • Curtis MA, Kam M, Nannmark U, Anderson MF, Axell MZ, Wikkelso C, Holtas S, van Roon-Mom WM, Bjork-Eriksson T, Nordborg C, Frisen J, Dragunow M, Faull RLM, Eriksson PS (2007) Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science 315:1243-1249.
  • Waldvogel HJ, Curtis MA, Baer K, Rees MI, Faull RLM (2007) Immunohistochemical staining of post-mortem adult human brain sections. Nature Protocols 1:2719-2732.
  • Tippett LJ, Waldvogel HJ, Thomas SJ, Hogg VM, van Roon-Mom W, Synek BJ, Graybiel AM, Faull RLM (2007) Striosomes and mood dysfunction in Huntington's disease. Brain 130:206-221.
  • Pearson AG, Byrne UT, MacGibbon GA, Faull RLM, Dragunow M (2006) Activated c-Jun is present in neurofibrillary tangles in Alzheimer's disease brains. Neuroscience Letters 398:246-250.
  • Zhang S, Liu H, Liu J, Tse CA, Dragunow M, Cooper GJ (2006) Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic beta-cells. FEBS Journal 273:3779-3791.
  • Curtis MA, Faull RLM, Glass M (2006) A novel population of progenitor cells expressing cannabinoid receptors in the subependymal layer of the adult normal and Huntington's disease human brain. Journal of Chemical Neuroanatomy 31:210-215.
  • Hodges A, Strand AD, Aragaki AK, Kuhn A, Sengstag T, Hughes G, Elliston LA, Hartog C, Goldstein DR, Thu D, Hollingsworth ZR, Collin F, Synek B, Holmans PA, Young AB, Wexler NS, Delorenzi M, Kooperberg C, Augood SJ, Faull RLM, Olson JM, Jones L, Luthi-Carter R (2006) Regional and cellular gene expression changes in human Huntington's disease brain. Human Molecular Genetics 15:965-977.
  • Smith R, Chung H, Rundquist S, Maat-Schieman ML, Colgan L, Englund E, Liu YJ, Roos RA, Faull RLM, Brundin P, Li JY (2006) Cholinergic neuronal defect without cell loss in Huntington's disease. Human Molecular Genetics 15:3119-3131.
  • Cameron R, Dragunow M (2006) Transcriptional control of nerve cell death, survival and repair. In: Immediate-early genes in sensory processing, cognitive performance and neurological disorders (Pinaud R, Tremere L, eds), pp 223-242: Springer Science and Business Media, LLC.
  • Dragunow M, Greenwood JM, Cameron RE, Narayan PJ, O'Carroll SJ, Pearson AG, Gibbons HM (2006) Valproic acid induces caspase 3-mediated apoptosis in microglial cells. Neuroscience 140:1149-1156.
  • Gibbons HM, Dragunow M (2006) Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain Research 1084:1-15.
  • Graham ES, Ball N, Scotter EL, Narayan P, Dragunow M, Glass M (2006) Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway. Journal of Biological Chemistry 281:29085-29095.
  • Lind CR, Gray CW, Pearson AG, Cameron RE, O'Carroll SJ, Narayan PJ, Lim J, Dragunow M (2006) The mitogen-activated/extracellular signal-regulated kinase kinase 1/2 inhibitor U0126 induces glial fibrillary acidic protein expression and reduces the proliferation and migration of C6 glioma cells. Neuroscience 141:1925-1933.
  • van Roon-Mom WM, Hogg VM, Tippett LJ, Faull RLM (2006) Aggregate distribution in frontal and motor cortex in Huntington's disease brain. Neuroreport 17:667-670.
  • Young D, Dragunow M (2006) The role of adenosine in status epilepticus? In: Status Epilepticus: Mechanisms and Management (Wasterlain CG, Treiman DM, eds), pp 315-324: MIT Press.
  • Curtis MA, Penney EB, Pearson J, Dragunow M, Connor B, Faull RLM (2005) The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain. Neuroscience 132:777-788.
  • Pearson AG, Curtis MA, Waldvogel HJ, Faull RLM, Dragunow M (2005) Activating transcription factor 2 expression in the adult human brain: association with both neurodegeneration and neurogenesis. Neuroscience 133:437-451.
  • van Roon-Mom WM, Reid SJ, Faull RLM, Snell RG (2005) TATA-binding protein in neurodegenerative disease. Neuroscience 133:863-872. Dragunow M (2004) CREB and neurodegeneration. Frontiers in Bioscience 9:100-103.
  • Francis JS, Dragunow M, During MJ (2004) Over expression of ATF-3 protects rat hippocampal neurons from in vivo injection of kainic acid. Brain Research Molecular Brain Research. 124:199-203.
  • Glass M, van Dellen A, Blakemore C, Hannan AJ, Faull RLM (2004) Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors. Neuroscience 123:207-212.
  • Reid SJ, van Roon-Mom WM, Wood PC, Rees MI, Owen MJ, Faull RLM, Dragunow M, Snell RG (2004) TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease. Brain Research Molecular Brain Research. 125:120-128.
  • Tattersfield AS, Croon RJ, Liu YW, Kells AP, Faull RLM, Connor B (2004) Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease. Neuroscience 127:319-332.
  • Curtis MA, Connor B, Faull RLM (2003) Neurogenesis in the diseased adult human brain--new therapeutic strategies for neurodegenerative diseases. Cell Cycle 2:428-430.
  • Reid SJ, Rees MI, van Roon-Mom WM, Jones AL, MacDonald ME, Sutherland G, During MJ, Faull RLM, Owen MJ, Dragunow M, Snell RG (2003) Molecular investigation of TBP allele length: a SCA17 cellular model and population study. Neurobiology of Disease 13:37-45.
  • Baer K, Waldvogel HJ, During MJ, Snell RG, Faull RLM, Rees MI (2003) Association of gephyrin and glycine receptors in the human brainstem and spinal cord: an immunohistochemical analysis. Neuroscience 122:773-784.
  • Curtis MA, Penney EB, Pearson AG, van Roon-Mom WM, Butterworth NJ, Dragunow M, Connor B, Faull RLM (2003) Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain. Proceedings of the National Academy of Sciences of the United States of America 100:9023-9027.
  • Gibbons H, Sato TA, Dragunow M (2003) Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. Brain Research Molecular Brain Research. 110:63-75.
  • Pearson AG, Gray CW, Pearson JF, Greenwood JM, During MJ, Dragunow M (2003) ATF3 enhances c-Jun-mediated neurite sprouting. Brain Research Molecular Brain Research. 120:38-45.
  • Rees MI, Harvey K, Ward H, White JH, Evans L, Duguid IC, Hsu CC, Coleman SL, Miller J, Baer K, Waldvogel HJ, Gibbon F, Smart TG, Owen MJ, Harvey RJ, Snell RG (2003) Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor, and mutation analysis in hyperekplexia. Journal of Biological Chemistry 278:24688-24696.
  • Thompson-Vest NM, Waldvogel HJ, Rees MI, Faull RLM (2003) GABA(A) receptor subunit and gephyrin protein changes differ in the globus pallidus in Huntington's diseased brain. Brain Research 994:265-270.
  • Waldvogel HJ, Baer K, Snell RG, During MJ, Faull RLM, Rees MI (2003) Distribution of gephyrin in the human brain: an immunohistochemical analysis. Neuroscience 116:145-156.
  • Peterson TC, Peterson MR, Robertson HA, During M, Dragunow M (2002) Selective down-regulation of c-jun gene expression by pentoxifylline and c-jun antisense interrupts platelet-derived growth factor signaling: pentoxifylline inhibits phosphorylation of c-Jun on serine 73. Molecular Pharmacology 61:1476-1488.
  • Abraham WC, Logan B, Greenwood JM, Dragunow M (2002) Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus. Journal of Neuroscience 22:9626-9634.
  • Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RLM, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S (2002) Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. Proceedings of the National Academy of Sciences of the United States of America 99:4680-4685.
  • van Roon-Mom WM, Reid SJ, Jones AL, MacDonald ME, Faull RLM, Snell RG (2002) Insoluble TATA-binding protein accumulation in Huntington's disease cortex. Brain Research Molecular Brain Research. 109:1-10.
  • Schonberger SJ, Edgar PF, Kydd R, Faull RLM, Cooper GJ (2001) Proteomic analysis of the brain in Alzheimer's disease: molecular phenotype of a complex disease process. Proteomics 1:1519-1528.
  • Francois F, Godinho MJ, Dragunow M, Grimes ML (2001) A population of PC12 cells that is initiating apoptosis can be rescued by nerve growth factor. Molecular & Cellular Neurosciences 18:347-362.
  • Xu R, Janson CG, Mastakov M, Lawlor P, Young D, Mouravlev A, Fitzsimons H, Choi KL, Ma H, Dragunow M, Leone P, Chen Q, Dicker B, During MJ (2001) Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes. Gene Therapy 8:1323-1332.
  • Whitaker WR, Faull RLM, Dragunow M, Mee EW, Emson PC, Clare JJ (2001) Changes in the mRNAs encoding voltage-gated sodium channel types II and III in human epileptic hippocampus. Neuroscience 106:275-285.
  • Munkle MC, Waldvogel HJ, Faull RLM (2000) The distribution of calbindin, calretinin and parvalbumin immunoreactivity in the human thalamus. Journal of Chemical Neuroanatomy 19:155-173.
  • Rees MI, Watts P, Fenton I, Clarke A, Snell RG, Owen MJ, Gray J (2000) Further evidence of autosomal dominant congenital zonular pulverulent cataracts linked to 13q11 (CZP3) and a novel mutation in connexin 46 (GJA3). Human Genetics 106:206-209.
  • Edgar PF, Douglas JE, Cooper GJ, Dean B, Kydd R, Faull RLM (2000) Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia. Molecular Psychiatry 5:85-90.
  • Billinton A, Ige AO, Wise A, White JH, Disney GH, Marshall FH, Waldvogel HJ, Faull RLM, Emson PC (2000) GABA(B) receptor heterodimer-component localisation in human brain. Brain Research Molecular Brain Research. 77:111-124.
  • Dragunow M, Xu R, Walton M, Woodgate A, Lawlor P, MacGibbon GA, Young D, Gibbons H, Lipski J, Muravlev A, Pearson A, During M (2000) c-Jun promotes neurite outgrowth and survival in PC12 cells. Brain Research Molecular Brain Research. 83:20-33.
  • Glass M, Dragunow M, Faull RLM (2000) The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience 97:505-519.
  • McGowan DP, van Roon-Mom W, Holloway H, Bates GP, Mangiarini L, Cooper GJ, Faull RLM, Snell RG (2000) Amyloid-like inclusions in Huntington's disease. Neuroscience 100:677-680.
  • Walton MR, Gibbons H, MacGibbon GA, Sirimanne E, Saura J, Gluckman PD, Dragunow M (2000) PU.1 expression in microglia. Journal of Neuroimmunology 104:109-115.
  • Brickell KL, Nicholson LF, Waldvogel HJ, Faull RLM (1999) Chemical and anatomical changes in the striatum and substantia nigra following quinolinic acid lesions in the striatum of the rat: a detailed time course of the cellular and GABA(A) receptor changes. Journal of Chemical Neuroanatomy 17:75-97.
  • Munkle MC, Waldvogel HJ, Faull RLM (1999) Calcium-binding protein immunoreactivity delineates the intralaminar nuclei of the thalamus in the human brain. Neuroscience 90:485-491.
  • Edgar PF, Schonberger SJ, Dean B, Faull RLM, Kydd R, Cooper GJ (1999) A comparative proteome analysis of hippocampal tissue from schizophrenic and Alzheimer's disease individuals. Molecular Psychiatry 4:173-178.
  • Edgar PF, Douglas JE, Knight C, Cooper GJ, Faull RLM, Kydd R (1999) Proteome map of the human hippocampus. Hippocampus 9:644-650.
  • Waldvogel HJ, Kubota Y, Fritschy J, Mohler H, Faull RLM (1999) Regional and cellular localisation of GABA(A) receptor subunits in the human basal ganglia: An autoradiographic and immunohistochemical study. Journal of Comparative Neurology 415:313-340.