School of Medical Sciences

Human Neurodegenerative Diseases Group - projects

  • Correlation of the clinical profiles, chemical anatomical pathology and genotype in Huntington's disease (PI, RLMF)
  • Chemical neuroanatomical changes in a transgenic mouse model of Huntington's disease (PI, RLMF)
  • Neural stem cells and cell replacement in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease and Epilepsy) (PI, RLMF)
  • Microarray and proteome analysis of neurodegenerative diseases of the human brain – Huntington's disease (PI, RLMF)
  • The chemical anatomy and pathology of the Huntington's disease human brain (PI, HJW)
  • GABA A, GABA B and glycine receptors, and gephyrin in the basal ganglia of the normal and Huntington's disease brain (PI, HJW)
  • Nerve Cell Survival Pathways (PI, MD)
  • Nerve Cell Death Pathways (PI, MD)
  • Transcriptional Control of Axonal Regeneration (PI, MD)
  • Microglia , Astrocytes and Neurodegeneration (Neuro-inflammation, focus on human cell systems) (PI, MD)
  • Direct effects of Amyloid and Tau on neurons (PI, RS)
  • Development of a transgenic ovine model of Huntington's disease (HD) (PI, RS)
  • The Molecular Basis of the brain lesion in Huntington's disease (HD) (PI, RS)