Centre for Brain Research


Molecular, Cellular and Network Neurophysiology

Working together to improve lives

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About this team

This group aims to characterise the cellular and molecular mechanisms of neuronal damage occurring acutely during stroke, and chronically in Parkinson's disease.

Principal Investigator - Professor Janusz Lipski MD, PhD is a professor of Neurophysiology at the Department of Physiology and Centre for Brain Research in the Faculty of Medical and Health Sciences,. Visit Professor Lipski's department profile here

Associated Investigator - Dr Peter Freestone PhD is a former Aotearoa Fellow and a researcher at the Department of Physiology and Centre of Brain Research in the Faculty of Medical and Health Sciences. Visit Dr Freestone's department profile here.  

 

 

Team members


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Andrew Yee – PhD candidate

 

Yuhuni (Yvonne) Sun – Research Technician

 

Kathryn Todd – Honours student

 

Blaze Forbes – Summer student

 

Rashika Karunasinghe - PhD - AI      

   

Publications


For a full list of publications, visit Professor Janusz Lipski and Dr Peter Freestone's University pages.

Objectives


  • To better understand the organisation of the basal ganglia and the roles of dopamine and endocannabinoids  in controlling the function of this system  in physiological and pathophysiological conditions;
  • Identify novel therapeutic targets to improve treatment of Parkinson’s disease

 

Areas of interest


  • Pathophysiology of Parkinson’s disease and other brain disorders caused by dysfunction of dopaminergic neurons
  • The mechanisms by which dopamine controls the function of the basal ganglia
  • Novel effects of L-DOPA and endocannabinoids on nigral dopaminergic neurons
  • Regulation of dopamine uptake by brain dopaminergic systems
  • Neuronal connections within the basal ganglia

 

Acknowledgments