Centre for Brain Research


Clinical Neuroscience Laboratory

Principal Investigator


Research interests


Research in the Clinical Neuroscience Laboratory is focused on the study of brain plasticity and recovery in humans with neurological disorders, particularly stroke.  The laboratory is located within Auckland City Hospital and our research includes patients recovering from stroke and people without neurological disorders.

Our main goals are to research techniques for promoting neural plasticity and recovery after stroke, to develop tools for accurately predicting recovery parameters and selecting priming techniques, in order to tailor rehabilitation for individual patients, and to translate our research into clinical practice.

We work closely with physicians, allied health therapists and nursing staff at Auckland City Hospital, who provide invaluable assistance for our various projects.

Current projects


  • TRIO: Targeted Rehabilitation, Improved Outcomes - funded by the Health Research Council
  • HARTS: Hand and Arm Recovery Trajectory after Stroke - funded by the Neurological Foundation of New Zealand
  • BARISTa: Biomarkers And Recovery In STroke - funded by Brain Research New Zealand

 

Collaborators


 

Recent publications


Ackerley SJ, Stinear CM, Barber PA, Byblow WD. (in press) Priming sensorimotor cortex to enhance task-specific training after subcortical stroke. Clin Neurophysiol 10.1016/j.clinph.2013.11.020 JIF 3.1

Petoe MA, Byblow WD, de Vries EJ, Krishnamurthy V, Zhong CS, Barber PA, Stinear CM. (2014) A template-based procedure for determining white matter integrity in the internal capsule early after stroke. Neuroimage Clin 4:695-700

McNaughton H, Thompson S, Stinear C, Harwood M, McPherson KM. (2014) Optimizing the content and dose of rehabilitation in the first 12 months following stroke. Crit Rev Physical Rehab Med 26(1-2):27-50

Stinear CM, Barber PA, Petoe MA, Anwar S, Byblow WD. (2014) Bilateral priming accelerates recovery of upper limb function after stroke: A randomized controlled trial. Stroke 45(1):205-10

Shekhawat GS, Searchfield GD, Stinear CM. (2014) Randomized trial of transcranial direct current stimulation and hearing aids for tinnitus management. Neurorehab Neural Repair 28(5) 410-419

Shekhawat GS, Searchfield GD, Stinear CM. (2014) The relationship between tinnitus pitch and hearing sensitivity. Eur Arch Otorhinolaryngol 271(1):41-8

Petoe MA, Molina Jaque FA, Byblow WD, Stinear CM. (2013) Cutaneous anesthesia of the forearm enhances sensorimotor function of the hand. J Neurophysiol 109:1091-96

Shekhawat GS, Searchfield GD, Kobayashi K, Stinear CM. (2013) Prescription of hearing aid output for tinnitus relief. Int J Audiol 52(9):617-25

Shekhawat G, Stinear CM, Searchfield G. (2013) Transcranial direct current stimulation intensity and duration effects on tinnitus suppression. Neurorehab Neural Repair 27(2): 164-172

Stinear CM, Ackerley SJ, Byblow WD. (2013) Rehabilitation is initiated early after stroke, but most motor rehabilitation trials are not. A systematic review. Stroke 44:2039-45

Stinear CM, Ward NS. (2013) How useful is neuroimaging for predicting outcomes in stroke rehabilitation? Int J Stroke 8(1):33-7

Chollet F, Cramer SC, Stinear C, Kappelle LJ, Baron JC, Weiller C, Azouvi P, Hommel M, Sabatini U, Moulin T, Tardy J, Valenti M, Montgomery S, Adams H. (2013) Pharmacological therapies in post stroke recovery: recommendations for future clinical trials. J Neurol 10.1007/s00415-013-7172-z

Bradnam LV, Stinear CM, Byblow WD (2013). Ipsilateral motor pathways after stroke: implications for noninvasive brain stimulation. Front Hum Neurosci 7:184

Shekhawat G, Stinear CM, Searchfield G. (2013) Role of hearing aids in tinnitus intervention: A scoping review. JAAA 24(8):747-62

MacDonald H, Stinear CM, Byblow WD. (2012) Uncoupling response inhibition.  Journal of Neurophysiology, 108(5): 1492-1500

Stinear CM, Barber PA, Petoe M, Anwar S, Byblow WD. (2012) The PREP algorithm predicts potential for upper limb recovery after stroke.  Brain 135: 2427-2535

Lebon F, Lotze M, Stinear CM, Byblow WD. (2012) Task-dependent interaction between parietal and contralateral primary motor cortex during explicit versus implicit motor imagery. PLoS One 7(5):e37850

Byblow WD, Stinear CM, Smith MC, Bjerre L, Flaskager BK & McCambridge, AB. (2012)  Mirror symmetric bimanual movement priming can increase corticomotor excitability and enhance motor learning.  PLoS One 7(3):e33882

Bradnam LV, Stinear CM, Barber PA, Byblow WD (2012)  Contralesional hemisphere control of the proximal paretic upper limb following stroke.  Cereb Cortex 22(11):2662-2671.

Lebon F, Byblow WD, Collet C, Guillot A, Stinear CM. (2012) The modulation of motor cortex excitability during motor imagery depends on imagery quality. European Journal of Neuroscience 35(2):323-331