CBR Research published in Annals of Neurology

12 March 2019
Annals of Neurology

CBR research was recently published in Annals of Neurology, Volume 85, Number 3, March 2019. The paper is titled: Cerebellar degeneration correlates with motor symptoms in Huntington disease.

This study found that the loss of a type of nerve cell called a Purkinje cell in a brain region known as the neocerebellum is associated with the presentation of motor symptoms in Huntington’s disease.

Read the full paper

The paper was also featured in Huntington’s Disease News earlier in 2019. Read the Huntington’s News story.

Additionally an image from the paper was also featured on the March cover of Annals of Neurology (left)


A photomicrograph of a section through the cerebellum of a patient with mood, but not motor manifestations of Huntington's disease (HD), stained immunohistochemically for calbindin (brown) and counterstained with cresyl violet to show granule cells. Large, dark brown Purkinje cells are aligned along the border of the granule cell layer, and have healthy dendritic trees, while in cases with motor manifestations of HD, the Purkinje cells degenerate. See Singh-Bains et al., pp. 396–405

This is an image of a slice of human brain tissue from the Neurological Foundation of NZ Human Brain Bank. The brain slice is labelled with a stain to illustrate Large, dark brown Purkinje cells. These large cells are located in the cerebellum, which is a region we have identified to have a role in Huntington’s disease (HD). In HD patients with motor symptoms, these cells show signs of degeneration (sickness). In Huntington’s disease patients with mood disturbances, these cells are preserved. The small blue cells are called granule cells, which are among the smallest neurons in the brain!

Dr Malvindar Singh-Bains, Ph.D | Research Fellow