CBR Seminar: Of Mice and Men… and Worms: Regulators of Neuronal Plasticity and Neurodegeneration Event as iCalendar

22 August 2018

2 - 3pm

Venue: CBR Seminar Room 501-505

Location: Faculty of Medical and Health Sciences

Host: Centre for Brain Research

Cost: Free

Contact email: sarah.j.evans@auckland.ac.nz

Dr Asim Beg

Dr Asim Beg - Assistant Professor, Department of Phamacology, University of Michigan

Defining the mechanisms that govern the assembly, maturation and maintenance of neural circuits that underlie behavior is a fundamental goal in biology. Our lab focuses on identifying key regulators and signaling pathways that instruct neurons to establish and modify their synaptic connections and neuronal morphology. To this end, we use the mouse and Caenorhabditis elegans as model systems to identify and characterize critical genes and signaling pathways that regulate essential neurodevelopmental and regenerative processes such as synaptogenesis and axonal and dendrite guidance and growth. In addition to investigating how these processes are normally regulated, we examine how defects in specific pathways contribute to the etiology and pathology of prevalent neurological and neurodegenerative diseases. To accomplish these goals, we utilize a wide variety of state-of-the-art molecular, genetic, cellular, biochemical, electrophysiological and behavioral approaches. Currently, my laboratory is focused in two major directions: 1) molecular genetics of motor neuron disease, and 2) cytoskeletal regulation of neuronal arbor growth and plasticity.