CBR/SMS seminar: Understanding and restoring biometal homeostasis in neurodegeneration Event as iCalendar

19 June 2014

11am - 12pm

Location: Room 501-505, level 5, FMHS, University of Auckland, 85 Park Rd, Grafton

Speaker: Associate Professor Anthony White, Department of Pathology, The University of Melbourne

Neurodegenerative diseases are caused by complex molecular pathways resulting in common neuropathological outcomes including protein aggregation, neuroinflammation and neuronal cell degeneration. An increasingly well-recognised factor in these pathogenic changes is a loss of biometal homeostasis resulting in abnormal accumulation and function of copper, zinc, iron and additional key bioelements.

Our research has demonstrated that changes to neuronal and glial biometal metabolism are critical early changes in the neurodegenerative disease process. We have also demonstrated that bis(thiosemicarbazone)-metal complexes offer an exciting new approach to treatment of neurodegeneration by restoring abnormal biometal homeostasis.

These metal-complexes have generated robust protective outcomes in multiple cell and animals of Alzheimer’s, Parkinson’s, motor neuron and childhood neurodegenerative diseases and are currently being developed for clinical application.

This research has opened a new area of investigation into the molecular pathogenic basis of neurodegeneration and is leading to novel treatment approaches for a range of disorders.