PharmaTell seminar Event as iCalendar

09 April 2014

12 - 1pm

Venue: Room 505-364, Building 505, 85 Park Road, Grafton

Conducting polymer / liquid crystal hybrids towards tuneable bioactive delivery

Stimuli responsive controlled drug delivery offers promising benefits in pharmacotherapy where the drug release can be tuned externally based on patient needs. In this study, conducting polymers are grown within liquid crystals creating exciting materials which will be applied to triggered drug release.

Presented by: Dedeepya Uppalapati

Dedeepya came to New Zealand in 2012 after completing her Bachelor of Pharmacy and MS (pharm) in National Institute of Pharmaceutical Education and Research. She started her PhD in May 2013 with the School of Pharmacy.

A multi-step nanocarrier to deliver a novel hypoxia-activated prodrug for targeted anticancer chemotherapy

Liposomes were first discovered over 50 years ago and has since received considerable attention due to their potential to target solid tumours and reduce toxicity by exploiting the Enhanced Permeability and Retention effect. Low extracellular pH, ‘leaky’ vasculature and reduced oxygen prefusion (hypoxia) are main features of solid tumours. The overall aim of this PhD project is to exploit these characteristics to achieve tumour-specific delivery of a DNA-cytotoxin. SN 25860, a novel hypoxia-activated prodrug (HAP), is designed to selectively release cytotoxins in hypoxic regions, will be used as the model drug. In this presentation, some prelieminary results will be presented, including the influence of formulation variables on drug loading and stability.

Presented by Mimi Yang

Mimi graduated with a B.Pharm (Hons.) from the University of Auckland, School of Pharmacy in 2010. Upon registration as a Pharmacist, Mimi has worked in community, rural and clinical pharmacy in the Auckland and Waikato regions. She join Dr Zimei Wu’s research team in 2013 and began her doctoral research in targeted drug delivery. In her spare time, Mimi enjoys many outdoor pursuits including various types of water and snow sports.


For further information please contact: School of Pharmacy Administration Phone:+64 9 373 7599 ext 82851 Fax: +64 9 367 7192 Email: enquiries@auckland.ac.nz