Molecular Medicine & Pathology seminar: Staphylococcus aureus Superantigens and Cytolysins Promote Pathogenesis of Toxic Shock Syndrome Event as iCalendar

24 February 2014

3:30 - 4:30pm

Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton

Staphylococcus aureus , through its production of toxins, alters skin and mucosal barriers and dysregulates the immune system to cause severe diseases in humans. The first step to finding a treatment for a disease is to understand the root cause or mechanism. Therefore, the objective of our study is to determine the mechanism of action of the staphylococcal superantigen toxic shock syndrome toxin-1 (TSST-1) and the cytolysins, alpha-toxin and gamma-toxin, in their ability to cause inflammation and promote disease at the epithelial mucosal surface .

The purpose of our study is to provide insight into the pathogenesis of staphylococcal toxins at the mucosal epithelium and the contribution to TSS. Through studying the mechanism which superantigens and cytlolysins promote pathogenesis at the mucosal epithelium we have identified a potential novel therapeutic strategy in treatment of TSS. Thus, we conclude that local effects of superantigens and cytolysins at the vaginal mucosa are critical mediators to the pathogenesis of mTSS and transient inhibition of EGFR may be beneficial for treatment.

Presented by: Aaron Gillman , University of Minnesota

Anyone wanting to meet with Aaron should email Fiona Clow or Fiona Radcliff Email: