Molecular Medicine & Pathology seminar: Nothobranchius furzeri: A short-lived killifish as a new model for age research Event as iCalendar

18 February 2014

3:30 - 4:30pm

Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton

The annual fish Nothobranchius furzeri inhabits seasonal ponds in South-East Africa and is characterized by a short life cycle, which is preserved in laboratory strains. Different strains live between 3 and 12 months and are characterized by explosive growth, early sexual maturation, age-dependent physiological decline and the expression of aging biomarkers.  One focus of our work is on regeneration and its age-dependence. For this we study epimorphic regeneration of the caudal fin in Nothobranchius . As a second organ we analyze the kidney and its regenerative capacity. In both instances our morphological, cellular and molecular analyses show that regeneration is age-dependent. Concerning fin regeneration for example we found that aged fish terminated at 74 % regeneration of the amputated length, while the young fish regenerated their fins almost completely. The usefulness of a model organism in biomedicine depends on its amenability for genetic manipulation. As an important step in this regard we consider the establishment of transgenesis in N. furzeri , which we could achieve recently. This opens up new possibilities for the analysis of the role of individual genes in the aging process.

Presented by: Professor Christoph Englert , Leibniz Institute for Age Research - Fritz Lipmann Institute

Anyone wanting to meet with Professor Englert should email Alan Davidson a.davidson@auckland.acnz


For more information please contact: Robyn McDonald Email: r.mcdonald@auckland.ac.nz