Liggins Institute seminar: Quantitative Metabolomics and Medical Biomarkers Event as iCalendar

04 December 2013

4 - 5pm

Venue: Seminar Room 505-003, Building 505, 85 Park Road, Grafton

Despite billions of research dollars being spent on genome sequencing, GWA studies or large-scale proteomic efforts, very few “omics” discoveries have actually had a significant impact on patient care, new drug development, quality of life or overall life expectancy.  One of the central reasons for this failure lies in the fact that many of the “omics” techniques used today are relatively non-quantitative.

This inability to absolutely quantify levels of gene expression, to precisely measure protein abundance or to quantitatively distinguish between meaningful and meaningless mutations has rendered many “omics” discoveries unreliable and irreproducible. By learning from the struggles of past “omics” efforts and focusing on accurate, absolute quantification, I believe that metabolomics may be able to avoid these pitfalls.

In doing so, it may be able to make a long-term, meaningful contribution to improving human health and welfare.  In this presentation I will describe my laboratory’s efforts to develop a variety of quantitative metabolomic platforms for robust metabolite identification and quantification.  I will also describe some of the results of our work aimed at systematically characterizing all major human biofluids using these platforms.

I will then show how these data and these platforms can be used to discover and develop a number of metabolite biomarkers for a wide variety of diseases.  In particular, I will describe how quantitative metabolomics can be used to discover, assess and validate clinically useful biomarkers. These biomarkers could have a significant, positive impact on patient care, new drug development, quality of life and life expectancy.

Presented by: Professor David Wishart , Depts. of Computing Science, Biological Sciences, and Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada


For general information on this talk and the Liggins Seminar Series please contact:

Elise Donovan Email: e.donovan@auckland.ac.nz Phone: 64 9 923 477