Molecular Medicine & Pathology seminar: MRI bone oedema in rheumatoid arthritis – What is it and why does it matter? Event as iCalendar

07 November 2013

3:30 - 4:30pm

Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton

MRI bone marrow oedema is an important feature of rheumatoid arthritis. It is often present at the hands and wrists and associated with joint inflammation (synovitis). It has been shown in several large cohort studies to have negative implications for prognosis and is the strongest long-term predictor of bone damage (erosions). MRI bone oedema is prominent in patients with the most aggressive and disabling disease. Its histological correlate is osteitis, where the bone beneath the joint is invaded by an inflammatory and lymphoplasmacytic infiltrate.

Activated osteoclasts are adjacent to the osteitic lesion, suggesting a mechanistic link between bone inflammation and erosive damage. MRI bone oedema/osteitis is now regarded as a major rheumatoid lesion that is responsive to therapeutic intervention and is being used as an outcome measure in large clinical trials of new biological agents.

The Auckland Rheumatology Imaging group headed by Professor McQueen has been at the forefront of research into the place of MRI in RA for the last 15 years and first described the association between MRI bone oedema and erosion. This work will be the subject of this seminar.

Presented by: Professor Fiona M McQueen

For more information, please contact: Robyn McDonald Email: Phone: 373 7599 ext 86285