Auckland Cancer Society Research Centre seminar: The Macrophage Migration Inhibitory Factors: microenvironmental drivers of tumorigenesis Event as iCalendar

01 November 2013

1 - 2pm

Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton

Clear cell renal cell carcinomas (ccRCC) are characterized by biallelic loss of the von Hippel Lindau tumor suppressor and subsequent constitutive activation of the hypoxia inducible factors, whose transcriptional programs dictate major phenotypic attributes of kidney tumors.

The MIF family of cytokines is comprised of two hypoxia regulated factors that shape the tumor microenvironment.  Macrophage migration inhibitor factor (MIF) D-dopachrome tautomerase (DDT) share significant sequence and functional homology and are found to be coordinately expressed in the majority of ccRCC, serving both autocrine and paracrine functions to promote growth and aggressiveness of tumors. MIF is a widely-studied and pleiotropic cytokine implicated in a variety of diseases and cancers, and is the target of both small molecule and antibody-based therapies currently in clinical trials.  We have investigated roles for MIF and DDT in renal cancer, and have found significant overlap functions in controlling cell survival, tumor formation, and tumor- and endothelial-cellmigration.

Our findings identify DDT as a functionally redundant but more potent cytokine to MIF in cancer, and suggest that current attempts to inhibit MIF signaling may fail due to DDT compensation.

Presented by: Scott M. Welford , Ph.D. Assistant Professor of Radiation Oncology, Case Western Reserve University


For further information please contact: Euphemia Leung Email: e.leung@auckland.ac.nz