Obstetrics & Gynaecology seminar Event as iCalendar

27 September 2013

3:30 - 4:30pm

Venue: Seminar Room 505-003, Building 505, 85 Park Road, Grafton

“The expression of NALP3 inflammasome in endothelial cells in response to necrotic trophoblast debris”

The maternal syndrome of preeclampsia is characterized by a generalized systemic inflammatory based on both leukocytes and endothelium. In our past research we have found that endothelial cells have the ability to phagocytose the shedding trophoblast cellular materials and only phagocytosis of necrotic trophoblast debris can induce endothelial cell dysfunction. How endothelial cells distinguish apoptotic and necrotic trophoblast debris is unknown.  This work aimed to test the hypothesis that endothelial cells detect necrotic trophoblast debris via a multimeric inflammasome sensor protein complex called NALP3 inflammasome.

Presented by: Jia Wei

“The clinical significance of ER β in human cancer”

Oestrogen receptor alpha (ERα) and beta (ERβ) are ubiquitously expressed throughout the human body. These two receptors mediate opposing effects, with ERα being growth-stimulatory whilst ERβ is anti-proliferative.  Consequently, deregulated ER signalling has been implicated in various diseases including cancer. Despite having a tumour suppressive nature, ERβ and its clinical relevance in human cancers remains undervalued. This project will investigate the molecular role of ERβ in breast, colorectal and ovarian cancer, with the aim to use ERβ as a novel biomarker for tumour classification and prediction of treatment response. Further understanding may also allow the development of ERβ-targeted treatments to help improve outcomes of existing therapies in cancer patients.

Presented by: Angel Cheng

For more information please contact: Hazel Pannell Email: h.pannell@auckland.ac.nz