Maurice Wilkins Centre research seminar: Structure and mechanism of respiratory complex I, a giant molecular proton pump Event as iCalendar

24 September 2013

1 - 2pm

Venue: MAC 1 Seminar Room, Old Biology Building, 5 Symonds Street, Auckland

NADH-ubiquinone oxidoreductase (complex I) is the first and largest enzyme in the respiratory chain of mitochondria and many bacteria. Mutations in complex I lead to the most common human genetic disorders. It is an L-shaped assembly formed by the membrane and hydrophilic arms. We have determined all currently known atomic structures of complex I, starting from the hydrophilic domain, followed by the membrane domain and by the recent structure of the entire Thermus thermophilus complex (536 kDa, 16 subunits, 9 Fe-S clusters, 64 TM helices). Structures suggest unique mechanism of coupling between electron transfer and proton translocation via long-range conformational changes.

Presented by: Dr Leonid Sazanov , Mitochondrial Biology Unit, Medical Research Council, Cambridge, UK


For more information, please contact: Shaun Lott Email: s.lott@auckland.ac.nz