Auckland Cancer Society Research Centre seminar: A STING in the tale of DMXAA? Event as iCalendar

23 August 2013

1 - 2pm

Venue: Lecture Theatre 505-011, AMRF Auditorium, Building 505, 85 Park Road, Grafton

In this seminar we will present the recent evidence that point to the mammalian endoplasmic reticulum protein, STING (stimulator of interferon genes) as being the receptor in murine macrophages for DMXAA. STING, also known as MITA, ERIS, MPYS or TMEM173, is a frontline sensor of the innate immune system. It links the detection of foreign nucleic acids and bacterial components in the cytosolic space to the activation of NF-?B and IRF3 transcription factors leading to cytokine production. DMXAA binds strongly to murine STING, but not to human STING. Despite 89% homology between mSTING and hSTING, structural studies of the two homologues show considerable differences in the folding of the binding domain. These structural differences provide an explanation for the species-selectivity in the activity of STING agonists, including DMXAA. Challenges to the design of agonists specific for hSTING based on an XAA scaffold will be discussed.

presented by: Associate Professor Lai Ming Ching


For more information please contact:

Dr Jack Flanagan Email: j.flanagan@auckland.ac.nz