Maurice Wilkins Centre research seminar: Enzymatic fluorination and its application to PET Medical imaging Event as iCalendar

21 August 2013

3 - 4pm

Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton

The lecture will focus on the origin of the rare fluorometabolites.  It will  highlight the  fluorinase enzyme which was isolated from Streptomyces cattleya and is now over-expressed in E. coli. The enzyme catalyses the first step in the biosynthesis of fluoroacetate and 4-fluorothreonine, natural products of Streptomyces catteya.  More recently the fluorinase has been used to incorporate [18F]-fluoride into organic fluorine motifs, and their    applications in positron emission tomography (PET) will be described.     For example [18F]-5-fluoro-5-deoxyribose (FDR) has been used as a bioconjugation agent for radiolabelling bioactive peptides PET imaging.

Presented by: Professor David O’Hagan , University of St Andrews

For more information, please contact:

Rochelle Ramsay Email: