Molecular Medicine & Pathology seminar: Capturing pluripotent stem cells in mice and cattle Event as iCalendar

20 June 2013

3:30 - 4:30pm

Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton

Pluripotent stem cells (PSCs) naturally originate from early embryos or the germ line and can also be artificially induced from somatic cells. Under the right culture conditions, they proliferate indefinitely while retaining the ability to produce all adult cell types, including functional gametes, even after extensive genetic modification. Ever since they were first described in mouse, there has been an interest to derive analogous cells from farm animals. Livestock PSCs would expand basic research from small rodents to large mammals with greater relevance for human biology and disease modelling. They would also serve as unique reproductive tools for a range of biomedical and agricultural applications. However, all attempts to isolate PSCs in non-rodent species have been unsuccessful. I will discuss how this failure relates to species-specific cell signalling differences and challenges the idea of a conserved pluripotent ground state during mammalian embryogenesis.

Presented by: Dr Björn Oback , AgResearch, Ruakura Research Centre, Hamilton

Anyone wanting to meet with Dr Oback should email Peter Shepher demail: peter.shepherd@auckland.ac.nz


For more information please contact: Robyn McDonald Email: r.mcdonald@auckland.ac.nz Phone: 373 7599 ext 86285