Auckland Cancer Society Research Centre seminar: Killing tumours from the inside out: Bystander effects of hypoxia-activated prodrugs Event as iCalendar

24 May 2013

1 - 2pm

Venue: Robb Lecture Theatre, Room 501-B09, Basement Level, Building 501, 85 Park Road, Grafton

Tumour hypoxia can be exploited by hypoxia-activated prodrugs (HAPs), but most HAPs are activated only under extreme hypoxia whereas more moderately hypoxic cells probably confer resistance to radiotherapy and chemotherapy. The ability of active metabolites to diffuse locally from severely hypoxic zones (bystander effect) may therefore be critically important for their use. During my PhD studies under supervision of Professor Bill Wilson and Dr Kevin Hicks I developed, tested and used a spatially resolved pharmacokinetic/pharmacodynamic (SR-PK/PD) model to evaluate the contribution of bystander effects to activity of the HAP PR-104A. This model calculates spatial gradients of O2, prodrug and metabolite concentrations and resulting killing in a digitised 3D tumour microregion. The model was utilised to identify strategies for optimisation of HAPs and their clinical application. In this talk I will highlight the most important findings of my PhD thesis.


: Annika Foehrenbacher, PhD Student, Auckland Cancer Society Research Centre

** Open session **

For further information please contact

Jack Flanagan