PharmaTell seminar: Epithelial cell-targeting nanoparticles for oral delivery of protein drugs and the influence of mucus Event as iCalendar

20 May 2013

12 - 1pm

Venue: Room 505-364, Building 505, 85 Park Road, Grafton

Nanocarriers are considered promising vehicles for the oral delivery of peptide and protein drugs. However, one of the greatest challenges in developing an efficient nanocarrier for oral delivery is to overcome the absorption barrier of the intestinal mucosa, consisting of intestinal epithelial cells as well as the mucus layer. Epithelial cell-targeting nanoparticles conjugated with peptide ligands were prepared. Compared with unmodified nanoparticles, these nanoparticles showed enhanced drug internalization and transport across the mucus-secreting cell monolayer as well as the ligated ileum loop of rats. Finally, significantly enhanced bioavailabilities were obtained in vivo.

Speaker

: Yuan Huang, Professor and Vice Dean, Key Laboratory of Drug Targeting and Drug Delivery, Ministry of Education West China, School of Pharmacy, Sichuan University P.R. China

For further information please contact:

School of Pharmacy Administration

Phone: +64 9 373 7599 ext 82851

Fax: +64 9 367 7192

Email:

enquiries@auckland.ac.nz