Department of Physiology seminar: Cardiac insulin resistance: functional adaptations & autophagic demise Event as iCalendar

23 April 2013

1 - 2pm

Venue: Seminar Room 503-028, Building 503, 85 Park Road, Grafton

Existence of a diabetic cardiac pathology, independent of vascular abnormalities, has been well reported. Diffuse interstitial fibrosis throughout the diabetic myocardium (even in the absence of an acute coronary event), suggests widespread cardiomyocyte attrition and cytokine activity. Understanding cardiomyocyte cell survival detriment and functional adaptation in the insulin resistant heart is an important priority. Investigations with dietary fructose-induced diabetes have revealed that a specific, non-apoptotic form of programmed cell death, autophagy, plays a role in the insulin resistant heart. Significant early Ca2+ adaptations in diabetic cardiomyocytes may occur before cardiac functional impact is observable. This work identifies molecular targets for development of treatment strategies for effective intervention before disease progression to advanced diabetic cardiomyopathy

Preseanted by:

Dr Kim Mellor PhD

Kim Mellor received her Bachelor of Biomedical Science from the University of Otago in 2004 and completed her PhD in Physiology from the University of Melbourne in 2011.  Following a post-doctoral period in Melbourne, she has relocated to Auckland to take up a Rutherford Postdoctoral Research Fellowship in the Cardiac Energetics Research Group at the Auckland Bioengineering Institute.