Department of Physiology seminar: Optical control of neural activities: The development of new optogenetic tools Event as iCalendar

22 April 2013

1 - 2pm

Venue: Seminar Room 503-028, Building 503, 85 Park Road, Grafton

Recent developments of ‘optogenetic’ tools have allowed experimenters to optically manipulate cellular activities with high spatial and temporal precision. The expression of these ‘optogenetic’ proteins can be used to control membrane potentials and modify biochemical pathways in genetically-defined neurons, unravelling their roles in specific behaviour and neural circuit. Similar to the development of fluorescent proteins, many early versions of these tools have properties that are not ideal as research tools. In this talk, John will describe the development of some new optogenetic tools, including the improvements of channel rhodopsin’s for the excitation of neuronal membrane, and the development of a novel approach to inhibit synaptic release with light. The improvement of these tools should provide the experiments improved control and more flexibility in their investigation of neural circuit and behaviour

Presented by

Dr  John Y Lin