Molecular Medicine & Pathology seminar: Hypothalamic inflammation and nutrient sensing: Possible links between obesity, diabetes and Alzheimer's disease? Event as iCalendar

18 April 2013

3:30 - 4:30pm

Venue: Seminar Room 503-024, Building 503, 85 Park Road, Grafton

Increased consumption of saturated fatty acids in our Western diet leads to hypothalamic inflammation which is associated with the development of leptin and insulin resistance in the hypothalamus. My talk focuses on the brain as a primary insulin and leptin target organ. Impaired leptin and insulin signalling in the hypothalamus, the neuronal centre for the regulation of body weight, might link obesity with associated diseases. Particularly the highly evolutionary conserved WNT pathway and the JNK, IKK? pro-inflammatory pathways might link obesity and hypothalamic inflammation with the pathogenesis of type II diabetes and Alzheimer?s disease.

Speaker

: Dr Alex Tups, University of Marburg

Anyone wanting to meet with Dr Tups should email Peter Shepherd

email:

peter.shepherd@auckland.ac.nz

Followed by drinks and pizza