PharmaTell seminar: Formulation of proteins for pharmaceutical applications Event as iCalendar

01 March 2013

2 - 3pm

Venue: Seminar Room 503-020, Building 503, 85 Park Road, Grafton

Proteins are a steadily growing class of drugs for pharmaceutical applications. For example, proteins can be formulated as drug carriers, or proteins can be incorporated into various different matrices such as particles, gels, implants etc. Two examples of protein formulation will be presented in this talk.

Recombinant spider silk proteins have an outstanding position among the group of new biomaterials. Different morphologies such as implants, films, micro- and nanoparticles or other delivery devices can be prepared.

This talk will summarize efforts in designing a robust method for the production of spider silk particles in the nanometer size range from aqueous solutions. Subsequently, these particles were loaded with the model drug lysozyme and the loading mechanism was investigated in detail.

In the second example, protein-loaded powder particles for intradermal vaccination were prepared using collapse freeze-drying and subsequent cryo-milling.