Centre for Brain Research seminar: Will transcranial brain stimulation protocols ever be a useful therapeutic intervention after stroke? How to navigate through variation in response towards a reasonable effect size Event as iCalendar

07 February 2013

4 - 5pm

Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton

Professor John Rothwell’s current research projects include using neurophysiological techniques to study the mechanisms of neural plasticity that underpin motor learning, and using this knowledge to devise new therapeutic interventions for rehabilitation after stroke. The laboratory specialises in devising new techniques to study the physiology of the human motor system in intact, awake volunteers.

The work extends from the study of spinal or brainstem reflex systems to basal ganglia and cerebral cortex. This has provided insight into the mechanisms of action of deep brain stimulation for the treatment of Parkinson’s disease and dystonia and the disorganisation of cortical and brainstem circuitry in different forms of myoclonus.

The laboratory has a long experience in the use of transcranial magnetic stimulation (TMS) and has pioneered its use to study cortical connectivity, as a virtual lesion technique and as a method for provoking long-term changes in the excitability of cortical synapses. The laboratory has also devised new methods for repetitive TMS that lead to effects on brain function that outlast the period of stimulation. This gives insight into how the remainder of the brain reacts to changes in function of another part, as well as to possibilities for therapeutic applications in rehabilitation of brain injury or chronic disease