Liggins Institute Seminar: Regulation of human skeletal muscle and cardiac energy metabolism by hypoxia-inducible factor Event as iCalendar
26 October 2011
4 - 5pm
Venue: Lecture Theatre 039, Room 105S-039, Clocktower South Wing, City Campus.
In the cells of our body a number of events take place when we are exposed to inadequate oxygen supply. The hypoxia-inducible factor (HIF) family of transcription factors plays a key role in orchestrating cellular response to hypoxia. In this seminar, I will present results from experiments where Chuvash polycythaemic patients with elevated levels of HIF at normal oxygen tensions were studied. Experiments included cardiac and skeletal muscle investigations at rest, and in conditions of metabolic stress. The findings reveal a clear regulatory role for HIF on human metabolism, particularly during exercise.
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