Molecular Medicine and Pathology Seminar series: Examining the haematopoietic response to inflammatory stress, A zebrafish model of lymphangiogenesis Event as iCalendar
27 September 2011
3:30 - 4:30pm
Venue: Seminar Room 501-505, Building 501, 85 Park Road, Grafton
Examining the haematopoietic response to inflammatory stress
The zebrafish system is widely regarded as an excellent model in which to examine haematopoietic stem and progenitor cell development. Given the very accessible nature of the zebrafish innate immune system, we reasoned this system could be exploited to directly examine the influence of inflammation on blood cell production and haematopoietic stem and progenitor cell behaviour. Further understanding the reactive capacity of haematopoietic stem and progenitor cells has far-reaching implications, including enhancing ex vivo expansion of haematopoietic stem cells for therapeutic benefit. I will discuss a novel mechanism through which the haematopoietic stem and progenitor cell compartment expands and supplies in-demand granulocytic progeny in response to inflammatory stress.
Chris Hall
A zebrafish model of lymphangiogenesis
Aberrant lymphatic vessel formation underpins a number of important human diseases such as cancer metastasis, chronic inflammation and obesity. We have developed a novel zebrafish transgenic line which enables live-imaging of lymphangiogenesis in vivo. This transgenic has been used to identify new genetic components of lymphatic development and also to screen for novel anti-lymphatic drugs.
Jonathan Astin
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