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{"sheet":"Ask & Acquire","index":0,"n_rows":28,"n_cols":8,"rows_kept":28,"cut":false,"hidden":false,"merged":[[24,0,24,7],[25,0,25,7],[26,0,26,7],[18,1,18,7],[19,0,19,7],[20,0,20,7],[21,0,21,7],[22,0,22,7],[23,0,23,7],[17,1,17,2],[9,0,9,1],[9,2,9,7],[10,0,10,1],[10,2,10,7],[11,0,11,1],[11,2,11,7],[12,0,12,7],[13,1,13,2],[14,1,14,2],[15,1,15,2],[16,1,16,2],[6,0,6,1],[6,2,6,7],[7,0,7,1],[7,2,7,7],[8,0,8,1],[8,2,8,7],[5,0,5,7],[0,0,0,7],[1,0,1,7],[2,1,2,4],[2,6,2,7],[4,0,4,7]]}
["GATE  Ask & Acquire - for all study types"]
["Notes for use:  Enter text in yellow areas, replacing current text.  Help notes appear in movable boxes"]
["Assessed by:",null,null,null,null,"Date:"]
["Problem"]
["Describe the problem that led you to seek an answer from the literature (Replace the text in yellow areas on this sheet with your responses; you can increase the size of the yellow areas on this page by clicking on the line under the numbers on the left of the sheet and dragging down)  "]
["Step 1: Ask a focused 5-part question using PECOT framework \nnote : question doesn’t need to be grammatically correct sentence; main aim is to identify key terms for search (Step 2)\n"]
["State if question is your question or the study authors' question "]
["Population / patient / client",null,"Specify relevant patient/client/population group (be specific about: medical condition, age group, sex, etc.)"]
["Exposure (intervention/ target disorder/risk or prognostic factor) ",null,"Specify:  intervention(s) you want to find out about for RCTs & other intervention studies; OR Target disease/condition to be diagnosed for diagnostic test accuracy studies; OR risk/intervention factor for case-control studies: OR  risk/prognostic factor for cohort studies. Be reasonably specific\n"]
["Comparison\n(Control) \n",null,"Specify alternative intervention (e.g. nothing or usual care); OR typical health status of those without target disease/condition (e.g. disease free or other comorbidities) for diagnostic test accuracy studies; OR comparison factor you want to compare it with for case-control studies and cohort studies?"]
["Outcomes",null,"Specify: the relevant health/disease-related outcomes you would like to prevent/reduce for RCTs; the relevant test for diagnostic test accuracy studies; the relevant health/disease related outcome/s for case-control studies and cohort studies"]
["Time",null,"If appropriate, specify a relevant time period over which outcomes likely to occu. Time is not usually considered explicitly in a diagnostic test accuracy question.   "]
["Step 2: Acquire (search for) the best evidence using the PECOT framework "]
["PECOT item","Primary Search term",null,null,"Synonym 1",null,"Synonym 2"]
["Population / Participants / patients / clients","Enter key search terms Use MESH terms (from PubMed) if available, then text words.",null,"OR","Include relevant synonym \n\n","OR","Include relevant synonym \n\n","AND"]
["Exposure (Interventions)","As above",null,"OR","As above\n\n","OR","As above\n\n","AND"]
["Comparison (Control)","As above",null,"OR","As above\n\n","OR","As above\n\n","AND"]
["Outcomes","As above",null,"OR","As above\n\n","OR","As above\n\n","AND"]
["Time","Entry generally not required for search"]
["Limits & Filters: "]
["PubMed has Limits (e.g. age, English language, years) & PubMed Clinical Queries has Filters (e.g. study type) to help focus your search. List if used."]
["Databases searched and number of publications by database and whether a review or individual paper: "]
["List databases searched and number of reviews/individual papers per database: e.g. Cochrane, standard PubMed, Clinical Queries in PubMed, Google scholar etc"]
["Evidence Selected"]
["Enter full citation of publication you have selected/or been given to evaluate"]
["Justification for selection"]
["State main objectives of the study.\n\nExplain why you chose this publication for evaluation."]
[null,null,null,null,null,"Please contribute your comments and suggestions on this form to: ","rt.jackson@auckland.ac.nz"]

{"sheet":"Appraise","index":1,"n_rows":93,"n_cols":21,"rows_kept":93,"cut":false,"hidden":false,"merged":[[29,11,31,21],[13,8,13,9],[19,7,20,8],[17,0,33,0],[21,11,24,21],[26,7,26,10],[17,8,18,8],[26,1,27,6],[17,1,18,6],[19,1,25,6],[28,1,33,6],[32,7,32,10],[6,11,6,21],[7,7,7,10],[5,0,6,0],[6,1,6,2],[6,3,6,6],[7,11,9,21],[7,0,16,0],[9,7,9,10],[4,12,4,21],[23,7,23,10],[5,1,5,6],[4,1,4,2],[4,3,4,4],[4,5,4,7],[4,8,4,9],[4,10,4,11],[15,1,16,6],[9,1,11,6],[12,1,14,6],[7,1,8,6],[5,7,5,10],[5,11,5,21],[18,16,20,18],[14,11,17,21],[61,23,63,24],[55,18,57,21],[60,20,60,21],[63,20,63,21],[10,11,13,21],[55,5,55,11],[55,12,55,17],[56,5,56,8],[56,9,56,11],[56,15,56,17],[40,11,41,21],[36,11,37,21],[29,7,29,10],[32,11,33,21],[34,7,34,10],[18,11,20,15],[92,17,92,20],[57,12,57,14],[57,15,57,17],[58,18,58,20],[67,0,67,21],[74,0,74,21],[79,0,81,21],[60,5,60,6],[57,5,57,8],[56,1,57,4],[82,0,84,21],[65,2,65,3],[63,5,63,6],[66,5,66,6],[64,18,66,20],[59,2,59,3],[2,1,2,19],[55,0,66,0],[34,1,35,6],[72,11,72,12],[72,18,72,19],[57,9,57,11],[36,1,37,6],[38,11,39,21],[42,11,43,21],[44,11,46,21],[56,12,56,14],[38,1,50,6],[25,11,28,21],[19,9,20,10],[19,19,19,21],[17,9,18,9],[88,0,91,21],[85,0,87,21],[72,4,72,6],[76,0,78,21],[34,0,50,0],[63,1,63,2],[62,1,62,2],[68,0,69,21],[70,0,70,21],[34,11,35,21],[47,11,50,21],[45,7,45,10],[51,0,53,0]]}
["    ",null,null,null,null,null,null,null,null,null,"GATE Appraise - Intervention Studies RCT/Cohort & Risk/Cross-sectional Studies"]
["    ","Notes for use:  Enter study numbers in yellow areas.  Help notes appear in movable boxes."]
["    ","Enter study descriptions in orange areas. Don't overwrite headings in orange areas as headings & all text is replicated on overflow sheet  "]
[null,"The form calculates results and displays them in the green areas"]
[null,"Assessed by:",null,null,null,"Assessed when:",null,null,null,null,"Publication details:"]
[null,"STUDY DESIGN (PECOT)",null,null,null,null,null,"  STUDY NUMBERS - \nhang on GATE frame   ",null,null,null,"STUDY ERRORS (RAMBOMAN)"]
[null,"Study type:",null,null,null,null,null,null,null,null,null,"Recruitment appropriate to study goals / able to define who findings applicable to?"]
["Population","Describe Study Setting: (double click here in the brackets, to right of bolded heading to add text -write over these instructions, but not the bolded headings)  ",null,null,null,null,null,"Study Setting",null,null,null,"Setting & eligible population appropriate to goals & sufficiently well described?"]
[]
[null,"Describe Eligibility criteria:",null,null,null,null,null,"Eligible population"]
[null,null,null,null,null,null,null,null,null,null,null,"Participants likely to be reasonably similar to all Eligibles?  "]
[null,null,null,null,null,null,null,null,"Participant"]
[null,"Describe Recruitment(sampling) process:",null,null,null,null,null,null,"sample"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"Risk/prognostic profiles sufficiently described to define who findings applicable to?"]
[null,"% of invited eligibles who participated:"]
[]
["Exposure & Comparison","EG=Exposure (Intervention / Risk factor) Grp",null,null,null,null,null,null,"(EG)","(CG)"]
[null,null,null,null,null,null,null,null,null,null,null," Allocation to EG & CG done well?",null,null,null,null,"allocated randomly or by measurement?"]
[null,"Describe Exposure: how defined (& measured if not RCT):",null,null,null,null,null,"EG allocated ",null," CG allocated"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"If randomised: done well? concealed? EG & CG similar at baseline?"]
[]
[null,null,null,null,null,null,null,"dropped pre-intervention (RCT only)"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"If allocated by measurement: done well? done before outcomes? differences between EG & CG documented?"]
[null,"CG =  Comparison (Control or comparison intervention / Risk factor) Group",null,null,null,null,null," completed follow-up +/or intervention"]
[]
[null,"Describe Comparison: how defined (& measured if not RCT):"]
[null,null,null,null,null,null,null,"drop-outs / lost during/post-intervention",null,null,null,"Maintenance in allocated groups & on allocated interventions/exposures during study sufficient? Errors low enough for results to be valid? "]
[]
[]
[null,null,null,null,null,null,null,"Percentage lost to follow-up",null,null,null,"Completeness of follow-up high enough and similar in EG & CG?"]
[null,null,null,null,null,null,null,null,{"$f":"IF(egall=\"\",\"\",IF(egall >0,(1-egfollow/egall),0))","v":""},{"$f":"IF(cgall=\"\",\"\",IF(cgall>0,(1-cgfollow/cgall),0))","v":""}]
["Outcomes & Time","O = Outcomes: list 1°, 2° & adverse outcomes",null,null,null,null,null,"Categorical outcomes",null,null,null,"Compliance high enough?"]
[null,null,null,null,null,null,null,"a",null,null,"b"]
[null,"T = Time when outcomes counted (at what point in time or over what time period)",null,null,null,null,null,"+  ",null,null,null," Contamination low enough?"]
[]
[null,"Describe Outcomes & Time: how defined & how / by whom / when identified: ",null,null,null,null,null,null,null,null,null,"Co-interventions similar enough in EG & CG?"]
[null,null,null,null,null,null,null,"-  "]
[null,null,null,null,null,null,null,null,null,null,null,"Participants/Investigators blind to EG/CG status?"]
[null,null,null,null,null,null,null,"c",null,null,"d"]
[null,null,null,null,null,null,null,null,null,null,null,"Blind and Objective Outcome measures?"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"Outcomes measured accurately enough?"]
[null,null,null,null,null,null,null,"Numerical outcomes"]
[null,null,null,null,null,null,null,null,null,null,"mean"]
[null,null,null,null,null,null,null,null,null,null,"std dev","Follow-up time similar in EG & CG and sufficient to be meaningful?"]
[null,null,null,null,null,null,null,"or",null,null,"std error"]
[]
[]
[]
[null,null,null,null,null,"Report results per (e.g. per 100):",null,null,100,"persons"]
[]
[null,"Calculated Results (unadjusted) with",null,null,null,null,null,95,"% confidence intervals",null,null,null,null,null,null,"Z-score:",{"$f":"NORMSINV(1-((100-ci)/100)/2)","v":1.9599639845400536}]
["Calculated in GATE frame",null,null,{"$f":"TINV((100-ci)/100,egfollow+cgfollow-2)","v":{"$error":"#NUM!"}},null,{"$f":"\"Occurrence per \" & per & \" \" & \"persons\"","v":"Occurrence per 100 persons"},null,null,null,null,null,null,{"$f":"\"Exposure effects per \" & per & \" \" & \"persons\"","v":"Exposure effects per 100 persons"},null,null,null,null,null,"Number needed to treat (NNT) to prevent/cause   1 event"]
[null,"Outcome: ",null,null,null,"in exposure group",null,null,null,"in comparison group",null,null,"Relative effect",null,null,"Absolute effect"]
[null,null,null,null,null,"(EGO)",null,null,null,"(CGO)",null,null," (EGO/CGO)",null,null," (EGO-CGO)"]
[null,"Categorical outcome:"]
[null,null,"Intention to treat analyses",null,null,null,null,{"$f":"IF(aa=\"\",\"\",IF(egall=0,\"\",per*aa/egall))","v":""},null,null,{"$f":"IF(bb=\"\",\"\",IF(cgall=0,\"\",per*bb/cgall))","v":""},null,null,{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=0,\"\",IF(ittcgo=\"\",\"\",ittego/ittcgo)))","v":""},null,null,{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=\"\",\"\",ittego-ittcgo))","v":""},null,null,{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=\"\",\"\",per/(ittego-ittcgo)))","v":""}]
[null,null,null,{"$f":"ci & \"% CIs\"","v":"95% CIs"},null,{"$f":"IF(aa=\"\",\"\",IF(egall=0,\"\",per*(2*aa+zscore^2-zscore*SQRT(zscore^2+4*aa*(1-aa/egall)))/(2*(egall+zscore^2))))","v":""},null,{"$f":"IF(F61<>I61,\"to\",\"\")","v":""},{"$f":"IF(aa=\"\",\"\",IF(egall=0,\"\",per*(2*aa+zscore^2+zscore*SQRT(zscore^2+4*aa*(1-aa/egall)))/(2*(egall+zscore^2))))","v":""},{"$f":"IF(bb=\"\",\"\",IF(cgall=0,\"\",per*(2*bb+zscore^2-zscore*SQRT(zscore^2+4*bb*(1-bb/cgall)))/(2*(cgall+zscore^2))))","v":""},{"$f":"IF(J61<>L61,\"to\",\"\")","v":""},{"$f":"IF(bb=\"\",\"\",IF(cgall=0,\"\",per*(2*bb+zscore^2+zscore*SQRT(zscore^2+4*bb*(1-bb/cgall)))/(2*(cgall+zscore^2))))","v":""},{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=0,\"\",IF(ittcgo=\"\",\"\",EXP(LN(ittego/ittcgo) - zscore*SQRT(1/aa+1/bb-1/egall-1/cgall)))))","v":""},{"$f":"IF(M61<>O61,\"to\",\"\")","v":""},{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=0,\"\",IF(ittcgo=\"\",\"\",EXP(LN(ittego/ittcgo) + zscore*SQRT(1/aa+1/bb-1/egall-1/cgall)))))","v":""},{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=\"\",\"\",ittego-ittcgo - per*zscore*SQRT(aa*(egall-aa)/egall^3+bb*(cgall-bb)/cgall^3)))","v":""},{"$f":"IF(P61<>R61,\"to\",\"\")","v":""},{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=\"\",\"\",ittego-ittcgo + per*zscore*SQRT(aa*(egall-aa)/egall^3+bb*(cgall-bb)/cgall^3)))","v":""},{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=\"\",\"\",per/(ittego-ittcgo - per*zscore*SQRT(aa*(egall-aa)/egall^3+bb*(cgall-bb)/cgall^3))))","v":""},{"$f":"IF(S61=U61,\"\",IF(U61<=T60,IF(T60<=S61,\"to\",\"to ∞ to\"),\"to ∞ to\"))","v":""},{"$f":"IF(ittego=\"\",\"\",IF(ittcgo=\"\",\"\",per/(ittego-ittcgo + per*zscore*SQRT(aa*(egall-aa)/egall^3+bb*(cgall-bb)/cgall^3))))","v":""}]
[null,"Categorical outcome:"]
[null,"On-treatment:no",null,null,null,null,null,{"$f":"IF(aa=\"\",\"\",IF(egfollow=0,\"\",per*aa/egfollow))","v":""},null,null,{"$f":"IF(bb=\"\",\"\",IF(cgfollow=0,\"\",per*bb/cgfollow))","v":""},null,null,{"$f":"IF(otego=\"\",\"\",IF(otcgo=0,\"\",IF(otcgo=\"\",\"\",otego/otcgo)))","v":""},null,null,{"$f":"IF(otego=\"\",\"\",IF(otcgo=\"\",\"\",otego-otcgo))","v":""},null,null,{"$f":"IF(otego=\"\",\"\",IF(otcgo=\"\",\"\",IF(otego-otcgo=0,\"\",per/(otego-otcgo))))","v":""}]
[null,"complete f/u:yes",null,{"$f":"ci & \"% CIs\"","v":"95% CIs"},null,{"$f":"IF(aa=\"\",\"\",IF(egfollow=0,\"\",per*(2*aa+zscore^2-zscore*SQRT(zscore^2+4*aa*(1-aa/egfollow)))/(2*(egfollow+zscore^2))))","v":""},null,{"$f":"IF(F64<>I64,\"to\",\"\")","v":""},{"$f":"IF(aa=\"\",\"\",IF(egfollow=0,\"\",per*(2*aa+zscore^2+zscore*SQRT(zscore^2+4*aa*(1-aa/egfollow)))/(2*(egfollow+zscore^2))))","v":""},{"$f":"IF(bb=\"\",\"\",IF(cgfollow=0,\"\",per*(2*bb+zscore^2-zscore*SQRT(zscore^2+4*bb*(1-bb/cgfollow)))/(2*(cgfollow+zscore^2))))","v":""},{"$f":"IF(J64<>L64,\"to\",\"\")","v":""},{"$f":"IF(bb=\"\",\"\",IF(cgfollow=0,\"\",per*(2*bb+zscore^2+zscore*SQRT(zscore^2+4*bb*(1-bb/cgfollow)))/(2*(cgfollow+zscore^2))))","v":""},{"$f":"IF(otego=\"\",\"\",IF(otcgo=0,\"\",IF(otcgo=\"\",\"\",EXP(LN(otego/otcgo) - zscore*SQRT(1/aa+1/bb-1/egfollow-1/cgfollow)))))","v":""},{"$f":"IF(M64<>O64,\"to\",\"\")","v":""},{"$f":"IF(otego=\"\",\"\",IF(otcgo=0,\"\",IF(otcgo=\"\",\"\",EXP(LN(otego/otcgo) + zscore*SQRT(1/aa+1/bb-1/egfollow-1/cgfollow)))))","v":""},{"$f":"IF(otego=\"\",\"\",IF(otcgo=\"\",\"\",otego-otcgo - per*zscore*SQRT(aa*(egfollow-aa)/egfollow^3+bb*(cgfollow-bb)/cgfollow^3)))","v":""},{"$f":"IF(P64<>R64,\"to\",\"\")","v":""},{"$f":"IF(otego=\"\",\"\",IF(otcgo=\"\",\"\",otego-otcgo + per*zscore*SQRT(aa*(egfollow-aa)/egfollow^3+bb*(cgfollow-bb)/cgfollow^3)))","v":""},{"$f":"IF(otego=\"\",\"\",IF(otcgo=\"\",\"\",IF(otego-otcgo=0,\"\",per/(otego-otcgo - per*zscore*SQRT(aa*(egfollow-aa)/egfollow^3+bb*(cgfollow-bb)/cgfollow^3)))))","v":""},{"$f":"IF(S84=U64,\"\",IF(U64<=T63,IF(T63<=S64,\"to\",\"to ∞ to\"),\"to ∞ to\"))","v":""},{"$f":"IF(otego=\"\",\"\",IF(otcgo=\"\",\"\",IF(otego-otcgo=0,\"\",per/(otego-otcgo + per*zscore*SQRT(aa*(egfollow-aa)/egfollow^3+bb*(cgfollow-bb)/cgfollow^3)))))","v":""}]
[null,"Numerical outcome:"]
[null,null,"Analysis of means",null,null,null,null,{"$f":"IF(emean=\"\",\"\",emean)","v":""},null,null,{"$f":"IF(cmean=\"\",\"\",cmean)","v":""},null,null,{"$f":"IF(cmean<>0,IF(emean/cmean>0,emean/cmean,\"N/A\"),\"\")","v":""},null,null,{"$f":"IF(emean=\"\",\"\",IF(cmean=\"\",\"\",emean-cmean))","v":""}]
[null,null,null,{"$f":"ci & \"% CIs\"","v":"95% CIs"},null,{"$f":"IF(AND(ese=\"\",esdev=\"\"),\"\",IF(emean=\"\",\"\",emean - zscore*IF(ese>0,ese,esdev/SQRT(egfollow))))","v":""},null,{"$f":"IF(F67<>I67,\"to\",\"\")","v":""},{"$f":"IF(AND(ese=\"\",esdev=\"\"),\"\",IF(emean=\"\",\"\",emean + zscore*IF(ese>0,ese,esdev/SQRT(egfollow))))","v":""},{"$f":"IF(AND(cse=\"\",csdev=\"\"),\"\",IF(cmean=\"\",\"\",cmean-zscore*IF(cse>0,cse,csdev/SQRT(cgfollow))))","v":""},{"$f":"IF(J67<>L67,\"to\",\"\")","v":""},{"$f":"IF(AND(cse=\"\",csdev=\"\"),\"\",IF(cmean=\"\",\"\",cmean + zscore*IF(cse>0,cse,csdev/SQRT(cgfollow))))","v":""},{"$f":"IF(OR(AND(ese=\"\",esdev=\"\"),AND(cse=\"\",csdev=\"\")),\"\",IF(cmean=\"\",\"\",IF(rm=\"N/A\",\"N/A\",MAX(0,rm-(TINV((100-ci)/100,egfollow+cgfollow-2)*rm*SQRT(IF(ese>0,ese,IF(esdev>0,esdev/SQRT(egfollow),))^2/meg^2+IF(cse>0,cse,IF(csdev>0,csdev/SQRT(cgfollow),))^2/mcg^2))))))","v":""},{"$f":"IF(M67<>O67,\"to\",\"\")","v":""},{"$f":"IF(OR(AND(ese=\"\",esdev=\"\"),AND(cse=\"\",csdev=\"\")),\"\",IF(cmean=\"\",\"\",IF(rm=\"N/A\",\"N/A\",rm +(TINV((100-ci)/100,egfollow+cgfollow-2)*rm*SQRT(IF(ese>0,ese,IF(esdev>0,esdev/SQRT(egfollow),))^2/meg^2 + IF(cse>0,cse,IF(csdev>0,csdev/SQRT(cgfollow),))^2/mcg^2)))))","v":""},{"$f":"IF(OR(AND(ese=\"\",esdev=\"\"),AND(cse=\"\",csdev=\"\")),\"\",IF(cmean=\"\",\"\",md -(TINV((100-ci)/100,egfollow+cgfollow-2)*SQRT(IF(ese>0,ese,IF(esdev>0,esdev/SQRT(egfollow),))^2 + IF(cse>0,cse,IF(csdev>0,csdev/SQRT(cgfollow),))^2))))","v":""},{"$f":"IF(P67<>R67,\"to\",\"\")","v":""},{"$f":"IF(OR(AND(ese=\"\",esdev=\"\"),AND(cse=\"\",csdev=\"\")),\"\",IF(cmean=\"\",\"\",md +(TINV((100-ci)/100,egfollow+cgfollow-2)*SQRT(IF(ese>0,ese,IF(esdev>0,esdev/SQRT(egfollow),))^2 + IF(cse>0,cse,IF(csdev>0,csdev/SQRT(cgfollow),))^2))))","v":""}]
["Reported Results"]
[]
[]
["Analysis"]
[]
[null,null,null,"Intention to treat if RCT? ",null,null,null,null,null,null,"Adjusted if EG & CG different? ",null,null,null,null,null,null,"95% CIs or p-values given? "]
[]
["Summary"]
[]
["1. Study design (AMBOM): non-random error/bias sufficiently low for study to be valid? - consider amount & direction of bias:"]
[]
[]
["2. Study analyses (AN): analytical error sufficiently low for results to be valid? - were ITT analyses done? were adjusted analyses done if EG & CG diiferent at baseline?"]
[]
[]
["3. Study numbers: random error sufficiently low (95% CI narrow) for results to be meaningful? if no statistically significant effects, was study power/sample size sufficiently high?"]
[]
[]
["4. Study effect size: RD +/ or RR sufficiently large to be real and meaningful?"]
[]
[]
["5. Applicability (R):  if 1-4 ok, are findings likely to be applicable in practice?"]
[]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Please contribute your comments and suggestions on this form to: ","rt.jackson@auckland.ac.nz"]

{"sheet":"Appraise (print version)","index":2,"n_rows":81,"n_cols":3,"rows_kept":81,"cut":false,"hidden":false,"merged":[[67,0,67,2],[25,0,25,2],[57,0,57,2],[2,0,2,2]]}
[null,"GATE Appraise print version - this sheet replicates the text from GATE Appraise"]
[null,"If macros on, text boxes atomatically expand with additional text. Otherwise can be done manually. But only enter text on main appraise sheet "]
["STUDY QUESTION & DESIGN - describe with PECOT"]
["P - Participants"]
[null,{"$f":"Appraise!B8","v":"Describe Study Setting: (double click here in the brackets, to right of bolded heading to add text -write over these instructions, but not the bolded headings)  "}]
[]
[null,{"$f":"Appraise!B10","v":"Describe Eligibility criteria:"}]
[]
[null,{"$f":"Appraise!B13","v":"Describe Recruitment(sampling) process:"}]
[]
[null,{"$f":"Appraise!B16","v":"% of invited eligibles who participated:"}]
[]
["EG - Exposed Group [Intervention/Risk factor]"]
[]
[null,{"$f":"Appraise!B20","v":"Describe Exposure: how defined (& measured if not RCT):"}]
[]
["CG = Comparison Group [Control/ comparison intervention / factor]"]
[]
[null,{"$f":"Appraise!B29","v":"Describe Comparison: how defined (& measured if not RCT):"}]
[]
["O=Outcomes Primary (&2° / adverse)"]
["T - Time when outcomes counted (at what point in time or over what time period)"]
[]
[null,{"$f":"Appraise!B39","v":"Describe Outcomes & Time: how defined & how / by whom / when identified: "}]
[]
["STUDY ERRORS - assess using RAMBOMAN"]
["Recruitment appropriate to study goals / able to define who finidings applicable to?"]
[]
[null,{"$f":"Appraise!L8","v":"Setting & eligible population appropriate to goals & sufficiently well described?"}]
[]
[null,{"$f":"Appraise!L11","v":"Participants likely to be reasonably similar to all Eligibles?  "}]
[]
[null,{"$f":"Appraise!L15","v":"Risk/prognostic profiles sufficiently described to define who findings applicable to?"}]
[]
["Allocation to EG & CG done appropriately?"]
[]
[null,{"$f":"Appraise!L22","v":"If randomised: done well? concealed? EG & CG similar at baseline?"}]
[]
[]
[null,{"$f":"Appraise!L26","v":"If allocated by measurement: done well? done before outcomes? differences between EG & CG documented?"}]
[]
["Maintenance in allocated groups & on allocated interventions/exposures during study sufficient?"]
[]
[null,{"$f":"Appraise!L33","v":"Completeness of follow-up high enough and similar in EG & CG?"}]
[]
[null,{"$f":"Appraise!L35","v":"Compliance high enough?"}]
[]
[null,{"$f":"Appraise!L37","v":" Contamination low enough?"}]
[]
[null,{"$f":"Appraise!L39","v":"Co-interventions similar enough in EG & CG?"}]
[]
[null,{"$f":"Appraise!L41","v":"Participants/Investigators blind to EG/CG status?"}]
[]
["Blind and Objective measures?"]
[]
[null,{"$f":"Appraise!L45","v":"Outcomes measured accurately enough?"}]
[]
["Analysis"]
["Reported result"]
[null,{"$f":"IF(ISBLANK(Appraise!A69),\"\",Appraise!A69)","v":""}]
["Intention to treat if RCT? "]
[null,{"$f":"IF(ISBLANK(Appraise!E73),\"\",Appraise!E73)","v":""}]
["Adjusted if EG & CG different? "]
[null,{"$f":"IF(ISBLANK(Appraise!L73),\"\",Appraise!L73)","v":""}]
["95% Cis or p-values given? "]
[null,{"$f":"IF(ISBLANK(Appraise!S73),\"\",Appraise!S73)","v":""}]
[]
["Summary"]
[]
[null,{"$f":"Appraise!A77","v":"1. Study design (AMBOM): non-random error/bias sufficiently low for study to be valid? - consider amount & direction of bias:"}]
[]
[null,{"$f":"Appraise!A80","v":"2. Study analyses (AN): analytical error sufficiently low for results to be valid? - were ITT analyses done? were adjusted analyses done if EG & CG diiferent at baseline?"}]
["\n"]
[]
[null,{"$f":"Appraise!A83","v":"3. Study numbers: random error sufficiently low (95% CI narrow) for results to be meaningful? if no statistically significant effects, was study power/sample size sufficiently high?"}]
[]
[null,{"$f":"Appraise!A86","v":"4. Study effect size: RD +/ or RR sufficiently large to be real and meaningful?"}]
[]
[null,{"$f":"Appraise!A89","v":"5. Applicability (R):  if 1-4 ok, are findings likely to be applicable in practice?"}]
[]
["Please contribute your comments and suggestions on this form to: ",null,"rt.jackson@auckland.ac.nz"]

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["GATE Apply - for all study types"]
["Notes for use:  Enter text in yellow areas"]
["Assessed by:",null,"Date:"]
["Step 4: Apply. Consider/weigh up all factors & make (shared) decision(s) to act"]
["The X-Factor"]
[]
["Epidemiological evidence: are the results of this study consistent with other epidemiological evidence relevant to the decision(s) (e.g. ideally from systematic reviews)?  ",null,"What Case circumstances (e.g. disease process/ co-morbidities /social situation) specifically related to the problem may impact on the decision(s)? "]
[" (Replace this text; you can increase the size of the yellow areas on this sheet by clicking on the line under the numbers on the left of the sheet and dragging down)"]
["System features: are there any system constraints or enablers that may impact on the decision(s)?  ",null,"What Values & Preferences may need to be considered in making the decision(s)?  "]
[]
["Decision(s): taking into account all the factors above what is the best decision(s) for this problem?     "]
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["Step 5: What are the implications of this decision(s) for practice?\n"]
["What are the wider considerations of this decision(s) for usual practice? Should it change usual practice in any way? "]
[]
[null,null,"Please contribute your comments and suggestions on this form to: ","rt.jackson@auckland.ac.nz"]

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