BPhEd, BSc, PhD
Associate Professor in Reproductive Science
Associate Professor Shelling is head of the Medical Genetics Group. His laboratory is interested in understanding the molecular changes that occur during the development of disease, particularly those occurring in gynaecological disorders, including cancer. An understanding of the important changes will eventually provide an opportunity to improve the early detection of disease, and to target more effective treatment.
Andrew is extensively involved in teaching reproduction, genetics and cancer at the University of Auckland.
Andrew has recently served as President of the New Zealand branch of the Human Genetics Society of Australasia and as an Associate Editor for the Human Reproduction journal, which is one of the leading journals in the area of Reproductive research. Andrew has recently been appointed to be a Trustee for the Nurture Foundation for Reproductive Research (http://www.nurture.org.nz) and is a member of the Advisory Committee for Assisted Reproductive Technologies (ACART) (http://www.acart.health.govt.nz).
Selected Publications
1.
Shelling AN. Mutations in inhibin and activin genes
associated with human disease. Molecular and Cellular Endocrinology, manuscript
accepted
2.
Dudding TE, Lawrence O, Winship I, Forgen G,
Scott RJ, Shelling AN. Comparative Genomic Hybridization (CGH) for the Detection of
Sub-Microscopic X Chromosomal Abnormalities in a cohort of Women with Premature
Ovarian Failure. Human Reproduction (2010) 25(12): 3159-60
3.
Shelling AN, Premature ovarian failure, Reproduction
(2010) 140: 633–641
4.
Mehta S, Shelling
A, Muthukaruppan A, Lasham A, Blenkiron C, Print C. Predictors
and Prognosticators for Cancer Medicine. Therapeutic Advances in Medical
Oncology, manuscript accepted
5.
Chand AL,
Harrison CA and Shelling AN. Inhibin and Premature Ovarian
Failure. Molecular Human
Reproduction (2010) 16(1): 39-50
6. Ramachandran A, Marshall ES, Love DR, Baguley BC and
Shelling AN. Activin is a potent growth suppressor of epithelial ovarian
cancer cells. Cancer Letters (2009) 285(2): 157-165
7.
Shelling AN. Progress
in the study of genetic disease: bringing new light to complex problems. Postgraduate
Medical Journal, 85(1008): 505-7
8.
Woad KJ,
Pearson SM, Harris SE, Gersak K, Shelling AN. Investigating the association between INHA promoter polymorphisms and premature ovarian
failure. Fertility and Sterility (2009) 91(1): 62-6
9.
Grant VJ, Irwin RJ, Standley N, Shelling AN, Chamley L. Sex
of bovine embryos may be related to mothers’ pre-ovulatory follicular
testosterone. Biology of Reproduction (2008) 78(5): 812-5
10. Eddy C-A, MacCormick J, Crawford JR, Chung
S-K, Rees MI, Skinner JR, Shelling AN. Identification of large gene rearrangements in KCNQ1 and KCNH2 in patients with long QT syndrome. Heart Rhythm (2008) 5(9): 1275-81
11. Ramachandran A, Black MA, Shelling AN and Love DR. Microarrays:
analysis of signalling pathways. Methods in Molecular Medicine (2008) 141:
115-130
12.
Shelling AN, Ferguson LR. Genetic
variation in human disease, and a new role for copy number variants. Mutation
Research (2007) 622, 33-41
13.
Chand
AL, Ooi GT, Goodman S, Makanjee YM, Stanton P, Farnworth P, Fayad K, Harrison
CA, Shelling AN, Robertson DM.
Functional analysis of the human inhibin A257T mutation and its potential role
in premature ovarian failure. Human Reproduction (2007) 22(12): 3241-3248
14.
Watkins
WJ, Harris SE, Craven M, Vincent AL, Winship IM, Gersak K, Shelling AN. An investigation into FOXE1 polyalanine tract length
in premature ovarian failure and BPES. Molecular Human Reproduction (2006) 12
(3): 145-149
15.
Chand
AL, Ponnampolam A, Harris SE, Winship IM, Shelling
AN. Mutational analysis of GDF9 and BMP15 as candidate genes in premature
ovarian failure. Fertility and Sterility (2006) 86(4): 1009-1012
16.
Watkins
WJ, Umbers AJ, Woad KJ, Winship IM, Gersak K, Shelling AN. Mutational screening of FOXO3A and FOXO1A in
premature ovarian failure. Fertility and Sterility (2006) 86(5): 1518-1521
17.
Harris
SE, Chand AL, Winship IM, Gersak K, Nishi Y, Yanase T, Nawata H, Shelling AN. INHA promoter polymorphisms are associated with Premature Ovarian
Failure. Molecular Human Reproduction (2005) 11(11): 779-784
18.
Chiu,
W.C.C., Ericson, E.K.L., Sole, C.A., Shelling,
A.N., Chamley, L.W. SPRASA, a novel sperm protein involved in immune
mediated infertility. Human Reproduction (2004) 19(2):
243-249
19.
Sisco,
B., Hagemann, L.J., Shelling, A.N.,
Pfeffer, P.L. Isolation of genes differentially expressed in dominant and
subordinate bovine follicles. Endocrinology (2003) 144(9): 3904–3913
20. Harris S.E., Chand A.L., Gersak, K,
Aittomaki, K., Winship, I., Shelling AN.
Identification of novel mutations in FOXL2 associated with premature ovarian
failure. Molecular Human Reproduction (2002) 8(8): 729-733
21. Francis-Thickpenny, K.M.,
Richardson, D.M., van Ee, C.C., Love, D.R., Winship, I.M., Baguley, B.C.,
Chenevix-Trench, G., Shelling, A.N. Analysis
of the TGF? functional pathway in epithelial ovarian cancer. British Journal of Cancer, (2001), 85(5):
687-691
22.
Shelling, A.N. and Foulkes, W. Molecular genetics
of ovarian cancer. Molecular Biotechnology, (2001), 19(1): 13-28
23.
Odunsi,
K. van Ee, C.C., Ganesan, T.S., and Shelling,
A.N. Evaluation of the possible protective role of adeno-associated virus
type 2 infection in HPV associated premalignant disease of the cervix.
Gynecologic Oncology (2000) 78 (3), 342-345
24.
Shelling, A.N., Burton, K.A., van Ee, C.C., France,
J.T., Farquhar, C.M., Milsom, S.R., Love, D.R., Gersak, K, Aittomaki, K., and
Winship, I. Inhibin: A Candidate Gene For Premature Ovarian Failure. Human
Reproduction (2000) 15(12), 2644-2649
25.
Kasprzak,
L. Foulkes, W.D. and Shelling, A.N.
Hereditary ovarian carcinoma. British Medical Journal (1999) 318, 786-789
26.
Shelling, A.N. Role of p53 in drug resistance in
ovarian cancer. The Lancet (1997) 349, 744-745
27.
Shelling, A.N., Cooke, I. and Ganesan, T.S. The
genetic analysis of ovarian cancer. British Journal of Cancer (1995) 72,
521-527
