Climacteric/menopause

Prevention and treatment of short-term problems

Medical treatments:

• Antidepressants
• Antifibrinolytics
• Antihypertensives
• Clonidine
• Hormone replacement therapy
  [P] Hormone replacement therapy versus placebo for menopausal symptom scores
  [R] Local oestrogen for vaginal atrophy in postmenopausal women
  [R] Oestrogen and progestogen hormone replacement therapy for peri-menopausal and post-menopausal women: weight and body fat distribution
  [R] Hormone replacement therapy in postmenopausal women: endometrial hyperplasia and irregular bleeding
  [R] Oral oestrogen replacement therapy versus placebo for hot flushes
• Naloxone
• Oral contraceptive pill
• Essential fatty acids (eg, evening primrose oil)
• Other hormones
  [P] Dehydroepiandrosterone for postmenopausal women
  [P] Testosterone for peri- and postmenopausal women Non-hormonal therapy
  [P] Non-hormonal therapy for hot flushes in postmenopausal women P] Hormone replacement therapy versus placebo for menopausal symptom scores

Psychological interventions

Exercise

Nutrition/diet

• Phytoestrogens
  [P] Phytoestrogens for menopausal symptoms

Alternative therapies

• Chinese herbs
• Acupuncture

Prevention and treatment of medium term problems

Medical treatments

• Hormone replacement therapy

Prevention and treatment of long term problems

• [P] Hormone replacement therapy for perimenopausal and postmenopausal women

[P] = Protocol