Principal investigators
Staff
Research
In the last few years, our bone cell and molecular biology research group has investigated
the correlative relationship between fat mass and bone mass that we observed in
clinical studies. A number of peptide hormones have been recently identified that
positively influence fat and bone mass and we are studying these hormone effects
on bone metabolism using in vitro and in vivo models.
Selected references
Menaa C., Barsony J., Reddy S.V., Cornish J., Cundy T., Roodman G.D. (2000). 1,25-Dihydroxyvitamin
D3 hypersensitivity of osteoclast precursors from patients with Paget's disease.
Journal of Bone & Mineral Research 15:228-36.
Cornish J., Callon K.E., King A.R., Cooper G.J., Reid I.E. (1998). Systemic administration
of amylin increases bone mass, linear growth, and adiposity in adult male mice.
American Journal, of Physiology 275 (4 Pt 1):E694-9.
