Multicellular layers are a model of the tumour extravascular compartment. They were
developed by our group to study tumour extravascular transport and are now used
worldwide to answer many research questions.
HT29 Multicellular layer grown submerged in culture medium for 3 days
Recent publications on multicellular
layers
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Pruijn, F.B., Sturman, J., Liyanage, S., Hicks, K.O., Hay, M. P., Wilson, W.R. Extravascular
transport of drugs in tumor tissue: Effect of lipophilicity on diffusion of tirapazamine
analogues in multicellular layer cultures. J. Med. Chem. 2005, 48, 1079–1087.
Recent presentations on
multicellular layers
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Hicks KO, Siim BG, Pruijn FB, Hsu R, Secomb TW, Dewhirst MW, Wilson WR. Modeling
of tirapazamine distribution and cytotoxicity in one-dimension and in a mapped three-dimensional
window chamber microvascular network: implications for analogue development. Proc
Am Assoc Cancer Res 2003;44: 906-7.
