Hicks, K.O., Pruijn, F.B., Secomb, T.W., Hay, M.P., Hsu, R., Brown, J.M., Denny, W.A., Dewhirst, M. W., Wilson, W. R. Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs. Journal of the National Cancer Institute, 2006, 98(16), 1118-1128. | Full Text |

Pruijn, F.B., Sturman, J., Liyanage, S., Hicks, K.O., Hay, M. P., Wilson, W.R. Extravascular transport of drugs in tumor tissue: Effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures. J. Med. Chem. 2005, 48, 1079–1087. | Full Text |

Hicks, K.O., Siim B.G., Pruijn F.B., Wilson, W.R. Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: implications for extravascular transport and activity in tumors. Radiat Res. 2004, 161, 656-66. | Full Text |

Hicks, K.O., Pruijn, F.B., Sturman, J.R., Denny, W.A., Wilson, W.R. Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures. Cancer Res. 2003, 63, 5970-7. | Full Text |

Wilson, W.R., Pullen, S.M., Hogg, A., Hobbs, S.M., Pruijn, F.B., Hicks, K.O. In vitro and in vivo models for evaluation of GDEPT: quantifying bystander killing in cell cultures and tumors. In: Springer CJ, editor. Suicide Gene Therapy: Methods and Reviews. Totowa: Humana Press, 2003. p. 403-32. | Humana Press | Pubmed |

Baguley B.C., Hicks K.O., Wilson W.R. Tumour cell cultures in drug development. In: Baguley BC, Kerr DJ, editors. Anticancer Drug Development. San Diego: Academic Press; 2002. p. 269-84.

Wilson, W.R., Pullen, S.M., Hogg, A., Helsby, N.A., Hicks, K.O., Denny, W.A. Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures . Cancer Res. 62 (5):1425-1432, 2002. | Full Text |

Hicks, K.O., Pruijn, F.B., Baguley, B.C., Wilson, W.R. Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells. J Pharmacol Exp Ther. 2001, 297, 1088-98. | Full Text |

Siim, B.G., Hicks, K.O., Pullen, S.M., van Zijl, P.L., Denny, W.A., Wilson, W.R. Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Cytotoxicity, DNA binding, cellular uptake, and metabolism. Biochem Pharmacol. 2000, 60, 969-78. | Pubmed |

Wilson, W.R. and Hicks, K.O. Measurement of extravascular drug diffusion in multicellular layers. Br.J.Cancer 79 (9-10):1623-1626, 1999. | Pubmed |

Hicks, K.O., Fleming, Y., Siim, B.G., Koch, C.J., Wilson, W.R. Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. Int J Radiat Oncol Biol Phys 1998, 42, 641-9. | Pubmed |

Hicks, K.O., Ohms, S.J., van Zijl, P.L., Denny, W.A., Hunter, P.J., Wilson, W.R. An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours. Br J Cancer 1997, 76, 894-903. | Pubmed |