Background
I obtained my veterinary training and BVSc from the Massey University and PhD in
Pharmacology from The University of Auckland.
Research activity
My research involves the use of multicellular layers (MCL) to investigate the extravascular
transport of anticancer drugs. Multicellular layers are a model for the tumour extravascular
compartment similar to multicellular spheroids but their planar geometry diffusion
studies to be performed in diffusion chambers to assess drug transport.
Results of MCL studies require interpretation by modelling drug transport in tumours
constrained by tumour geometry and blood/plasma drug pharmacokinetics. In collaboration
with Dr Timothy Secomb
at The University of Arizona and
Dr Mark Dewhirst at
The Tumor Microcirculation Laboratory, Duke University, we have developed
a spatially resolved 3-dimensional PK/PD model for the extravascular transport of
hypoxic cytotoxins.
Download this programme.
Dr Timothy Secomb
Dr Mark Dewhirst
The Tumor Microcirculation Laboratory
These techniques can be used to assist in drug design programs in order to introduce
PK/PD and, in particular, extravascular transport early in the drug design process.
