In the development of anticancer drugs, it is increasingly important to measure their concentrations
accurately in blood and tissues. The ACSRC has extensive facilities for extracting
drug from blood and tissues and analysing the concentrations of the drug and its
breakdown products which are usually metabolites produced in the body.
We offer world class training in the use of high performance liquid chromatography and mass
spectrometry, and our bioanalysis cluster provides support for pharmacokinetic studies
in the development of our drugs as well as servicing other departments in the University.
Mass spectrometry
We use mass spectrometry to measure drug concentrations with very high sensitivity
and identify drug metabolites in blood and tissues
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Agilent Triple Quadrupole Mass Spectrometer
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Agilent LC/MS Mass Spectrometer
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Agilent Ion Trap Mass Spectrometer
High performance liquid chromatography
We make extensive use of HPLC for high throughput quantitation of drug concentrations
in our in vitro and in vivo pharmacokinetic studies
User Charges
Costs for using the facilities are outlined in the table below.
Non-commercial rates are intended for public good grant funded research, whereas commercial rates refer to commercially funded research (including HOD accounts).
All new users are required to undergo a one hour training session with our Senior Technician; the charge for which is equivalent to the hourly rate of the machine being used.
A grant number MUST be supplied for all bookings that are made. Cancellations of less than one days notice will be charged for the time booked (unless a replacement user is organised by the person who has made the booking).
Equipment
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Non-commercial (Rate/hour)
|
Commercial (Rate/hour)
|
|
QQQ |
$60.00 |
$90.00 |
|
LC/MS |
$30.00 |
$45.00 |
|
Ion Trap |
$50.00 |
$75.00 |
|
HPLC |
$20.00 |
$30.00 |
Contact person
Recent related publications
- Patel K, Lewiston D, Gu Y, Hicks KO, Wilson WR (2007) Analysis
of the hypoxia-activated dinitrobenzamide mustard phosphate pre-prodrug PR-104 and
its alcohol metabolite PR-104A in plasma and tissues by liquid chromatography-mass
spectrometry. J Chromatogr B Analyt Technol Biomed
Life Sci 856: 302-311
- Wilson WR, Hicks KO, Pullen SM, Ferry DM, Helsby NA, Patterson
AV (2007) Bystander effects of bioreductive drugs: potential for exploiting pathological
tumor hypoxia with dinitrobenzamide mustards. Radiat Res 167: 625-636
