MBChB 209 - Principles of Medicine
Welcome to the MBChB 209 Principles of
Medicine website
MBChB 209 official course description
Clinical Pharmacology Section
Learning Outcomes
Develop, through study of pharmacological principles a framework of knowledge that
forms the basis for the safe and effective use of medicines in clinical practice.
Introduction to Pharmacology
- Define a receptor and describe the principles of affinity, efficacy and potency
and the differences between competitive and non-competitive antagonism and inverse
agonism.
- Describe the role of receptors, enzymes, ion channels and transporters in drug action.
- Describe the different signalling pathways for G-protein coupled receptors, tyrosine
kinase inhibitors, ligand gated ion channels and nuclear receptors.
- Describe the anatomical and functional organisation and pathophysiological significance
of the autonomic nervous system.
- Describe the synthesis, storage and release of noradrenaline and acetylcholine and
intracellular signalling pathways involved in their action.
- Describe the different classes of drugs that affect autonomic neurotransmission,
their mode of action and clinical uses.
Clinical Pharmacology
- Define volume of distribution, clearance and half-life.
- Describe factors that affect absorption and describe the major pathways of drug
elimination and how factors influence them, including enzyme induction and inhibition,
lead to drug interactions.
- Describe the Emax model of drug action.
- Explain the difference between predictable and unpredictable adverse drug reactions,
and how these may be minimised.
- Describe the mechanisms of common examples of poisoning and approaches to treatment
and prevention.
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