Auckland City Hospital Neurology Department is the only
neurology department for the Auckland
and Northland regions and, as such, has extensive clinical experience.
There are active clinical and pharmaceutical company sponsored research studies
in neurological disorders, particularly cerebrovascular diseases, brain imaging,
movement disorders, epilepsy, multiple sclerosis and neurogenetics.
Current research projects include national and international phase II and III studies
examining therapeutic agents/strategies in human subjects.
Research details
Current research funding base
- Julius Brendel Trust for staff
- Pharmaceutical trial funding
Current research projects
- Auckland regional community stroke study
- Echoplanar imaging thrombolysis evaluation trial
- Atrial fibrillation secondary prevention
- Cardiothoracic surgery neuroprotection trial
- Pharmaceutical industry sponsored neuroprotective acute stroke trial
- Pharmaceutical industry sponsored secondary prevention in atrial fibrillation
Facilities / Technology platform
- Auckland City Hospital, particular interest in brain imaging
Educational activities / community linkages
Publications
- Butcher K, Parsons MW, MacGregor L, Barber PA, Chalk J, Bladin C, Levi C, Kimber
T, Schultz D, Fink J, Tress BM, Donnan GM, Davis SM for the EPITHET investigators.
Refining the perfusion-diffusion mismatch hypothesis. Stroke. 2005;36:1153-1159.
- McNaughton H, Barber PA, Gommans J. Nowitz M. Management problems of spontaneous
intracerebral haemorrhage. Hospital Medicine. 2005;66:229-234.
- Barber PA, Gommans J. Tissue plasminogen activator approved for stroke (editorial).
NZ Med J. 2005;118(1214):U1432.
- McAlister H, Barber PA, Clark M, Fenelon M, Fink J, Harwood M et al. The management
of people with atrial fibrillation and flutter. McAlister H, ed. 2005. Wellington:
New Zealand Guidelines Group.
- Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN et al for the recombinant
activated factor VII intracerebral haemorrhage trial investigators (incl Barber
A. Principal investigator New Zealand). Recombinant activated factor VII for acute
intracerebral haemorrhage. N Engl J Med. 2005;352:777-785.
- Barber PA, Charleston AJ, Anderson NE, Spriggs DA, Bennett P, Thomas K, Baker YK.
Changes in stroke care at Auckland Hospital between 1996 and 2001. NZ Med J. 2004;117
No 1190: ISSN1175 8716.
- Barber PA, Parsons MW, Desmond PM, Donnan GM, Tress BM, Davis SM. Use of PWI and
DWI Measures in the Design of “Proof of Concept” Stroke Trials. Journal of Neuroimaging.
2004:14:123-3.
- Baskett J, McNaughton H, Anderson NE, Barber PA, Cookson T, Dady K, Fink J, et al.
Life after stroke: New Zealand guideline for the management of stroke. Baskett JJ,
Mc Naughton H, eds. 2003. Wellington: Stroke Foundation of New Zealand and the New
Zealand Guidelines Group.
- Barber PA, Davis SM. Limitations of current brain imaging modalities in stroke.
In: Davis SM, Fisher M, Warach S, eds. MRI in Stroke. Cambridge 2003: Cambridge
University Press. Chapter 2. Pages15-29.
- Butcher K, Parsons MW, Chalk J, Barber A, Donnan GM, Desmond PM, Tress BM, Davis
SM. Perfusion thresholds in acute stroke thrombolysis. Stroke. 2003;34:2159-2164.
- Gommans J, Barber A, McNaughton H, Hanger HC, Bennett P, Spriggs D, Baskett JJ.
Stroke rehabilitation services in New Zealand. NZ Med J. 2003;116 No 1174. ISSN
11758716.
- Baird TA, Parsons MW, Barber PA, Desmond PM, G, Tress BM, Colman P, Jerrums G, Chambers
B, Davis SM. The influence of diabetes mellitus and hyperglycemia on stroke incidence
and outcome. J Clin Neurosci. 2003;9:618-626.
- Gerraty RP, Parsons MW, Barber PA, Darby DG, Desmond PM, Tress BM, Davis SM. Examining
the lacunar hypothesis with diffusion and perfusion MRI. Stroke. 2002;33:2019-2024.
- Parsons MW, Barber PA, Desmond PM, Darby DG, Byrnes G, Tress BM, Davis SM. Acute
hyperglycemia in PWI/DWI mismatch patients leads to poorer stroke outcome. Ann Neurol.
2002;52:20-28.
- Parsons MW, Barber PA, Darby DG, Chalk J, Rose S, Desmond PM, Gerraty RP, Tress
BM, Donnan GA, Davis SM. Diffusion and perfusion weighted MRI predicts response
to thrombolysis in stroke. Ann Neurol. 2002;51:28-37.
- Barber PA, Anderson NE, Bennett P, Gommans J. Acute stroke services in New Zealand.
NZ Med J. 2002;115 No 1146:3-6.
- Parsons MW, Barber PA, Davis SM. Relationship between severity of MR perfusion deficit
and DWI lesion evolution (Letter). Neurology. 2002;58:1707.
- Desmond PM, Lovell AC, Rawlinson AA, Parsons MW, Barber PA, Yang Q, Li T, Darby
DG, Gerraty RP, Davis SM, Tress BM. The value of ADC maps in early cerebral ischemia.
AJNR: American Journal of Neuroradiology. 2001;22:1260-1267.
- Parsons MW, Yang Q, Barber PA, Darby DG, Desmond PM, Gerraty RP, Tress BM, Davis
SM. Perfusion MRI maps in hyperacute stroke: relative cerebral blood flow most accurately
identifies tissue destined to infarct. Stroke. 2001;32:1581-1587.
- Baird AE, Dambrosia J, Dambrosia Q, Chaves C, Silver B, Barber PA, Parsons M, Darby
D, Davis, S, Caplan LR, Edelman RR, Warach S. A three-item scale for the early prediction
of stroke recovery. Lancet. 2001;357:2095-2099.
- Hirano T, Read SJ, Abbott DF, Baird AE, Yasaka M, Infeld B, Barber PA, Davis SM,
McKay WJ, Donnan GA. Prediction of the final infarct volume within 6 h of stroke
using single photon emission computed tomography with technetium-99m hexamethylpropylene
amine oxime. Cerebrovasc Dis. 2001;11:119-27.
- Barber PA, Consolo HK, Darby DG, Desmond PM, Gerraty RP, Yang Q, Tress BM, Davis
SM. Comparison of perfusion MRI with HM-PAO SPECT in chronic stroke. Cerebrovasc
Dis. 2001;11:128-36.
- Gerraty RP, Parsons MW, Barber PA, Darby DG, Davis SM. The volume of lacunes (Letter).
Stroke. 2001;32:1937-1938.
- Parsons MW, Li T, Barber PA, Yang Q, Darby DG, Desmond PM, Gerraty RP, Tress BM,
Davis SM. Combined 1H MRS and diffusion weighted MR imaging improves the prediction
of stroke outcome. Neurology. 2000;55:498-506.
- Barber PA, Anderson NE, Vincent A. Morvan’s syndrome associated with voltage-gated
K+ channel antibodies. Neurology. 2000;54:771-772.
- Davis SM, Tress BM, Barber PA, Darby DG, Parsons M, Gerraty RP, Yang Q, Li T, Donnan,
GA, Desmond PM. Echoplanar Magnetic Resonance Imaging in Acute Stroke. J Clin Neuroscience.
2000;7:3-8.
- Darby DG, Parsons MW, Barber PA, Davis SM. Significance of acute multiple brain
infarction on diffusion-weighted imaging. (Letter) Stroke. 2000:31:2266-2268.
- Barber PA, Darby DG, Davis SM. Disturbed diffusion and X-ray hypoattenuation in
acute stroke, (Letter). Stroke. 2000;31:233.
- Barber PA, Darby DG, Desmond PM, Gerraty RP, Yang Q, Li T, Jolley D, Donnan GA,
Tress BM, Davis SM. Identification of major ischemic change: diffusion-weighted
imaging versus computed tomography. Stroke. 1999; 30:2059-2065.
- Yang Q, Tress BM, Barber PA, Darby DG, Gerraty RP, Desmond PM, Li T, Davis SM. Evolution
of apparent diffusion coefficient and anisotropy in acute ischemic stroke. Stroke.
1999;30:2382-2390.
- Barber PA, Davis SM, Darby DG, Desmond PM, Gerraty RP, Yang Q, Jolley D, Donnan
GA, Tress BM. Absent middle cerebral artery flow predicts the presence and evolution
of the ischemic penumbra. Neurology. 1999;52:1125-32.
- Darby DG, Barber PA, Gerraty RP, Desmond PM, Yang Q, Parsons M, Li T, Tress BM,
Davis SM. Pathophysiologic topography of acute ischemia using combined diffusion-weighted
and perfusion MRI. Stroke. 1999;30:2043-2050.
- Barber PA, Davis SM, Infeld I, Baird AE, Donnan GA, Jolley D, Lichtenstein M. Spontaneous
reperfusion following ischemic stroke is associated with improved outcome. Stroke.
1998;29:2522-2528.
- Barber PA, Darby DG, Desmond PM, Yang Q, Gerraty RP, Jolley D, Donnan GA, Tress
BM, Davis SM. Prediction of stroke outcome with echoplanar diffusion- and perfusion-weighted
magnetic resonance imaging. Neurology 1998;51:418-426.
- Barber PA, Davis SM. Single-photon emission computed tomography-derived relative
hypoperfusion volume after ischemic stroke, (Letter). Stroke. 1999;30:1733-1734.
- Charleston AJ, Barber PA, Bennett P, Spriggs DA, Harris RG, Anderson NE. Management
of stroke in Auckland Hospital in 1996. NZ Med J. 1999;112:71-74. Barber PA, Chambers
ST, Parkin PJ. Australian paralysis tick bite. NZ Med J. 1994:107:252-253.
